Publications by authors named "Vanessa V Da Silva"
Determination of pharmaceutical compounds in hospital wastewater and their elimination by advanced oxidation processes.
J Environ Sci Health A Tox Hazard Subst Environ Eng
February 2018
This study investigates the mineralization efficiency, i.e. removal of total organic carbon (TOC) in hospital wastewater by direct ozonation, ozonation with UV radiation (O/UV), homogeneous catalytic ozonation (O/Fe) and homogeneous photocatalytic ozonation (O/Fe/UV).
View Article and Find Full Text PDFAmoxicillin (AMX) is a widely used penicillin-type antibiotic whose presence in the environment has been investigated. In this work, the degradation of the AMX in aqueous solutions by ozonation, ozonation with UV radiation (O/UV), homogeneous catalytic ozonation (O/Fe) and homogeneous photocatalytic ozonation (O/Fe/UV) was investigated. The performance results have been compared in terms of removal of amoxicillin and total organic carbon (mineralization efficiency).
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- This study investigated the effects of Pothomorphe umbellata extract on skin damage caused by UVB radiation in hairless mice.
- Results showed that UVB exposure decreased thymine dimer-positive and apoptotic cells, while increasing p53 and proliferating cell nuclear antigen-positive cells.
- After prolonged UVB exposure, treatment with P. umbellata led to reduced skin hyperplasia and an increase in protective p53-positive cells, indicating its potential to protect against UVB-induced skin damage.
Article Synopsis
- Exposure to UV radiation increases the production of matrix metalloproteinases (MMPs), which are enzymes that break down cellular structures, making them targets for therapeutic interventions.
- The study investigated the effects of the plant Pothomorphe umbellata's ethanolic root extract on two specific MMPs, MMP-2 and MMP-9, finding that the extract inhibited these enzymes more effectively than the isolated active compound 4-nerolidylcatechol (4-NC).
- Results demonstrated that P. umbellata could inhibit MMP-9 activity in vivo after UVB exposure, supporting its potential use in preventing skin damage and possibly treating skin cancer.
Article Synopsis
- Pothomorphe umbellata, known for its antioxidant and photoprotective properties, is being considered for cosmetic and pharmaceutical applications due to the compound 4-nerolidylcathecol (4-NC) found in its roots.
- The study assessed the photostability, chemical stability, and SPF of P. umbellata root extract in a gel formulation using high-performance liquid chromatography and UV spectrophotometry.
- Results showed that 4-NC remained stable at lower temperatures but degraded at 45°C; after UV exposure, its SPF was low (3.35), indicating that its antioxidant effects are more significant than its sun protection capabilities.
In this work we evaluated the influence of topical application of P. umbellata root extract gel, containing 0.1% of 4-nerolidylcathecol, on the antioxidant network in UV-induced oxidative damage in hairless mouse skin.
View Article and Find Full Text PDFAntioxidants such as vitamins E and C are known to play a significant role in ameliorating or preventing oxidative damage to the skin. However, to provide a satisfactory protection they must first permeate the skin, which serves as a permeation barrier. In this study we evaluated the influence of three different formulations (gel, gel-emulsion and emulsion) on the percutaneous absorption of 4-nerolidylcathecol, an antioxidant compound isolated from Pothomorphe umbellata root extracts.
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