Development of a SnO-based Ti/Sc generator for medical applications.

Towards application of Sc for diagnostic nuclear medicine, a Ti/Sc generator based on an inorganic resin has been evaluated. Unlike other radionuclide generators used for medical applications, the long-term retention of the parent Ti is vital due to its long half life. Herein, tin dioxide (SnO), a robust inorganic-based resin, has been synthesized and used as the stationary phase for a Ti/Sc generator.

Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals.

Three isotopes of scandium─Sc, Sc, and Sc─have attracted increasing attention as potential candidates for use in imaging and therapy, respectively, as well as for possible theranostic use as an elementally matched pair. Here, we present the octadentate chelator 3,4,3-(LI-1,2-HOPO) (or HOPO), an effective chelator for hard cations, as a potential ligand for use in radioscandium constructs with simple radiolabeling under mild conditions. HOPO forms a 1:1 Sc-HOPO complex that was fully characterized, both experimentally and theoretically.

Evaluation of hydroxamate-based resins towards a more clinically viable Ti/Sc radionuclide generator.

Several hydroxamate-based resins were synthesized and tested for use in Ti/Sc generator systems in small scale experiments (740 kBq Ti). The most promising resin was tested further in larger scale generator studies (37 MBq). This resin displayed impressive retention of Ti over several elutions, and high quantities of Sc were obtained in small volumes of dilute HCl eluents.

Current State of Ti/Sc Radionuclide Generator Systems and Separation Chemistry.

In recent years, there has been an increased interest in Ti/Sc generators as an onsite source of Sc for medical applications without needing a proximal cyclotron. The relatively short half-life (3.97 hours) and high positron branching ratio (94.

Metabolic Biomarkers Assessed with PET/CT Predict Sex-Specific Longitudinal Outcomes in Patients with Diffuse Large B-Cell Lymphoma.

In many cancers, including lymphoma, males have higher incidence and mortality than females. Emerging evidence demonstrates that one mechanism underlying this phenomenon is sex differences in metabolism, both with respect to tumor nutrient consumption and systemic alterations in metabolism, i.e.

Current State of Targeted Radiometal-Based Constructs for the Detection and Treatment of Disease in the Brain.

The continual development of radiopharmaceutical agents for the field of nuclear medicine is integral to promoting the necessity of personalized medicine. One way to greatly expand the selection of radiopharmaceuticals available is to broaden the range of radionuclides employed in such agents. Widening the scope of development to include radiometals with their variety of physical decay characteristics and chemical properties opens up a myriad of possibilities for new actively targeted molecules and bioconjugates.

Visions by Women in Molecular Imaging Network: Antiracism and Allyship in Action.

Recent events in America in 2020 have stimulated a worldwide movement to dismantle anti-Black racism in all facets of our lives. Anti-Black racism is, as defined by the Movement for Black Lives, a "term used to specifically describe the unique discrimination, violence, and harm imposed on and impacting Black people specifically." In science, technology, engineering, and mathematics (STEM), we have yet to achieve the goal and responsibility to ensure that the field reflects the diversity of our lived experiences.

Alpha emitting nuclides for targeted therapy.

Targeted alpha therapy (TAT) is an area of research with rapidly increasing importance as the emitted alpha particle has a significant effect on inducing cytotoxic effects on tumor cells while mitigating dose to normal tissues. Two significant isotopes of interest within the area of TAT are thorium-227 and actinium-225 due to their nuclear characteristics. Both isotopes have physical half-lives suitable for coordination with larger biomolecules, and additionally actinium-225 has potential to serve as an in vivo generator.

Radioarsenic: A promising theragnostic candidate for nuclear medicine.

Molecular imaging is a non-invasive process that enables the visualization, characterization, and quantitation of biological processes at the molecular and cellular level. With the emergence of theragnostic agents to diagnose and treat disease for personalized medicine there is a growing need for matched pairs of isotopes. Matched pairs offer the unique opportunity to obtain patient specific information from SPECT or PET diagnostic studies to quantitate in vivo function or receptor density to inform and tailor therapeutic treatment.

Synthesis, characterization and biological studies of rhenium, technetium-99m and rhenium-188 pentapeptides.

Unlabelled: A pentapeptide macrocyclic ligand, KYCAR (lysyl-tyrosyl-cystyl-alanyl-arginine), has been designed as a potential chelating ligand for SPECT imaging and therapeutic in vivo agents. This study shows the synthesis and characterization of KYCAR complexes containing nonradioactive rhenium, Tc, or Re. The metal complexes were also biologically evaluated to determine in vivo distribution in healthy mice.

Adrenal Histoplasmosis.

An 89-year-old woman presented with seizure and hyponatremia. CT and MRI demonstrated mass-like enlargement of the adrenal glands and multiple pulmonary nodules. PET/CT performed to evaluate for metastatic disease demonstrated intense F-FDG uptake within enlarged adrenal glands.