Publications by authors named "Vanessa S Clarimundo"
Article Synopsis
- Rheumatoid arthritis (RA) is a disease that harms the joints, and certain cells called fibroblast-like synoviocytes (FLS) are important in how it works.
- Researchers studied how a special protein called gastrin-releasing peptide (GRP) and its receptor (GRPR) affect the behavior of FLS in mice, especially how they grow and spread.
- They found that GRP makes FLS more invasive, but if a blocker for GRPR is used, it stops this effect. This research might help develop new treatments for RA by understanding how GRP and GRPR work together.
Montanine is an alkaloid isolated from Rhodophiala bifida bulb with potential anti-arthritic activity. In this context, we evaluated whether montanine has a disease modifying anti-rheumatic activity in two arthritis models and its effect in vitro on lymphocyte proliferation and on invasiveness of fibroblast-like synoviocytes (FLS). Antigen-induced arthritis (AIA) was performed in Balb/C mice with methylated bovine serum albumin, and nociception and leukocytes migration into the knee joint were evaluated.
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