Central corneal thickness measurements with partial coherence interferometry, ultrasound, and the Orbscan system.

Objective: To compare the reliability of central corneal thickness measurements (CCT) obtained with partial coherence interferometry (PCI), ultrasound pachymetry, and the Orbscan system.

Design: Cross-sectional study.

Participants: Twenty healthy subjects with CCT measurements in both eyes.

Effect of accommodation and pupil size on the movement of a posterior chamber lens in the phakic eye.

Purpose: Although a posterior chamber phakic intraocular lens provides effective refractive correction of high myopia and hyperopia, mechanical contact between the implantable contact lens (ICL) and the crystalline lens and inadequate aqueous circulation in the prelenticular space could cause subcapsular opacification. To assess whether and to what extent such mechanical contact occurs, changes in the distance between the STAAR Collamer ICL and the crystalline lens under various conditions were investigated.

Design: Open pilot study.

Effect of optic edge design and haptic angulation on postoperative intraocular lens position change.

Purpose: To assess the effect of optic edge design and optic-haptic angulation of open-loop intraocular lenses (IOLs) on postoperative axial movement and the final position of the optic by measuring the anterior chamber depth (ACD) during the first postoperative year using partial coherence interferometry (PCI).

Setting: Department of Ophthalmology, Vienna General Hospital, Institute of Medical Physics, University of Vienna, Vienna, Austria.

Methods: In study 1, a 3-piece silicone IOL with nonangulated modified C-loop haptics (MicroSil, Dr.

Early objective assessment of intraocular inflammation after phacoemulsification cataract surgery.

Purpose: To evaluate the time course of blood-aqueous barrier (BAB) disturbance in the early period after small-incision cataract surgery.

Setting: Department of Ophthalmology, Vienna University, Vienna, Austria.

Methods: In a prospective study, 15 eyes of 15 patients with age-related cataract had small-incision cataract surgery by phacoemulsification with intraocular lens implantation.

Influence of operator experience on the performance of ultrasound biometry compared to optical biometry before cataract surgery.

Purpose: To compare measurements performed with the IOLMaster (Carl Zeiss, Meditec AG) with those obtained by applanation ultrasound (US) and manual keratometry and to evaluate the effect of operator experience on US biometry.

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: The axial length (696 eyes) and anterior chamber depth (ACD) (462 eyes) were measured in 377 patients with cataract using the IOLMaster and applanation US.

Effect of a fixed dorzolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat.

Purpose: To evaluate the effect of a fixed dorzolamide-timolol combination (Cosopt) on intraocular pressure (IOP) after small-incision cataract surgery with sodium chondroitin sulfate 4%-sodium hyaluronate 3% (Viscoat).

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: This prospective randomized study comprised 76 eyes of 38 patients scheduled for small-incision cataract surgery in both eyes.

After-cataract in adults with primary posterior capsulorhexis: comparison of hydrogel and silicone intraocular lenses with round edges after 2 years.

Purpose: To evaluate the potential of primary posterior continuous curvilinear capsulorhexis (PCCC) to prevent after-cataract 2 years after surgery and perform a bilateral comparison of 2 intraocular lens (IOL) materials, silicone and hydrogel.

Setting: Department of Ophthalmology, University of Vienna, Medical School, Vienna, Austria.

Methods: In this randomized patient- and examiner-masked study, 37 patients (74 eyes) with age-related cataract had bilateral small-incision cataract surgery with PCCC.

Short-term effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata.

Objective: To investigate the short-term effect of dorzolamide hydrochloride, a topical carbonic anhydrase inhibitor, on central corneal thickness in patients with cornea guttata.

Design And Methods: In this randomized, placebo-controlled, double-masked, 3-drug crossover study, 20 patients with cornea guttata (mean endothelial cell count, 1321 cells/mm2) and 8 healthy control subjects (mean endothelial cell count, 2483 cells/mm2) were included. Study medications included 2% dorzolamide hydrochloride (Trusopt 2% eye drops; Merck & Co Inc, Whitehouse Station, NJ), 0.

Corneal endothelial cell protection with a dispersive viscoelastic material and an irrigating solution during phacoemulsification: low-cost versus expensive combination.

Purpose: To evaluate the protective effect on corneal endothelial cells of a low-cost and an expensive combination of a dispersive viscoelastic material and an irrigating solution during phacoemulsification.

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: This prospective randomized examiner- and patient-masked study comprised 90 eyes of 45 consecutive patients with age-related cataract in both eyes.

Intraocular lens movement caused by ciliary muscle contraction.

Purpose: To investigate intraocular lens (IOL) movement, measured as a change in anterior chamber depth (ACD) caused by pilocarpine-induced ciliary muscle contraction.

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: In this prospective study, the ACD was measured using high-precision, high-resolution, dual-beam partial coherence interferometry in 62 pseudophakic eyes of 55 patients under pilocarpine- and cyclopentolate-induced ciliary muscle contraction and relaxation.

Comparison of anterior chamber depth measurement methods in phakic and pseudophakic eyes.

Purpose: To compare anterior chamber depth (ACD) measurements in phakic and pseudophakic eyes using a slit-beam photographic technique (IOLMaster, Carl Zeiss Meditec AG) with those obtained with the laboratory prototype version of partial coherence interferometry (PCI) and with conventional applanation ultrasound in phakic eyes.

Setting: Department of Ophthalmology, Vienna General Hospital, Vienna University, Vienna, Austria.

Methods: Thirty-three ACDs of 28 patients with age-related cataract were measured preoperatively with a slit-beam photographic technique (IOLMaster) and the prototype version of PCI.

Levels of adhesion molecules do not decrease after 3 months of statin therapy in moderate hypercholesterolaemia.

Studies in animals and humans indicate a pivotal role for adhesion molecules (AMs) in the pathogenesis of atherosclerosis. Whereas an association between hypercholesterolaemia and AM expression has been suggested, it is unclear whether lowering cholesterol decreases AM expression and release. We compared the effects of a 3-month treatment with standard doses of three different statins (atorvastatin, simvastatin and pravastatin) on plasma levels of circulating AM (cAM) in 75 hypercholesterolaemic patients in a randomized clinical trial.

Comparison of ultrasound pachymetry and partial coherence interferometry in the measurement of central corneal thickness.

Purpose: To compare central corneal thickness (CCT) measurements obtained with 3 ultrasound pachymeters and with partial coherence interferometry (PCI) and evaluate the effect of repeated contact by a pachymetry probe on corneal thickness.

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: Central corneal thickness was measured in 20 eyes of 20 healthy volunteers with 3 different ultrasound pachymeters (DGH 500, DGH Technology Inc.

Effect of an acrylic intraocular lens with a sharp posterior optic edge on posterior capsule opacification.

Purpose: To compare the posterior capsule opacification (PCO) inhibiting effect of the sharp posterior optic edge design of the Sensar OptiEdge AR40e intraocular lens (IOL) (Allergan Surgical) with that of the round-edged design of the Sensar AR40 IOL. Setting Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: This prospective randomized patient- and examiner-masked study comprised 106 eyes of 53 patients with bilateral age-related cataract.

Refractive outcome of cataract surgery using partial coherence interferometry and ultrasound biometry: clinical feasibility study of a commercial prototype II.

Purpose: To evaluate the refractive outcome of cataract patients 3 months postoperatively using optical biometry obtained with a prototype version (axial length measurement, ALM, Carl Zeiss Jena) of the commercial partial coherence interferometry (PCI) instrument (IOLMaster, Carl Zeiss Jena).

Setting: Department of Ophthalmology, Vienna General Hospital, and Institute of Medical Physics, University of Vienna, Austria.

Methods: Forty-five patients with age-related cataract in both eyes were scheduled for bilateral cataract surgery.