Publications by authors named "Vanessa Moraes de Andrade"

Background: Discussion of the benefits of moderate alcohol consumption is ongoing. Broadly, research focusing on ethanol consumption tends to report no benefits. However, studies that distinguish between different types of alcoholic beverages, particularly beers, often reveal positive effects.

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Type 2 diabetes mellitus (T2D) is a metabolic disease, which occurs largely due to unhealthy lifestyle. As oxidative stress is believed to promote T2D, by inducing damage to lipids, proteins, and DNA, appropriate dietary interventions seem critical to prevent, manage, and even reverse this condition. Brazil nuts (Bertholletia excelsa, H.

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  • The study investigates how voluntary physical exercise combined with chronic fructose consumption affects pregnant females and their offspring.
  • Findings show that fructose intake led to negative health changes in the mothers, while voluntary exercise improved these conditions and decreased genotoxic effects.
  • Offspring from mothers consuming fructose showed issues like altered food consumption and increased adiposity, but those whose mothers also exercised had better health outcomes.
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Caffeine is a widely consumed substance, and there is a discussion about its effects when ingested by women during pregnancy and lactation. We aimed to identify the genotoxic effects of caffeine in female mice that consumed it during pregnancy and lactation periods and its consequences in their offspring. Thirty-six couples of Swiss mice received water or caffeine (0.

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  • - The comet assay is a flexible method used to identify DNA damage in individual eukaryotic cells, applicable to various species from yeast to humans, detecting issues like DNA strand breaks and other forms of damage.
  • - Modifications to the protocol are necessary based on the specimen to minimize additional DNA damage during sample processing and to enhance the detection of damage differences.
  • - The method has been validated for various applications in research and has gained recognition as an in vivo genotoxicity test by the OECD, with guidelines provided for its use across different cell types and DNA damage assessments.
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Royal jelly (RJ) is a creamy white-yellow liquid that is secreted by the mandibular and hypopharyngeal glands of bees to nourish the larvae. RJ has gained increasing interest in recent years owing to its antioxidant potential. However, little is known about adequate RJ dosing and its effects on genetic material.

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The intrauterine environment is a critical location for exposure to exogenous and endogenous factors that trigger metabolic changes through fetal programming. Among the external factors, chemical compounds stand out, which include caffeine, since its consumption is common among women, including during pregnancy. Thereby, the aim of the present study was to evaluate the behavioral, genetic, and biochemical parameters in the offspring of female mice treated with caffeine during pregnancy and lactation.

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  • Inhalation of harmful particles, especially from cigarette smoke, triggers inflammation and oxidative stress, leading to chronic obstructive pulmonary disease (COPD).
  • The study explores the therapeutic effects of different concentrations of gold nanoparticles (GNPs) administered intranasally to mice exposed to cigarette smoke.
  • Results indicate that while higher doses of GNPs show strong anti-inflammatory effects, a mid-range dose (7.5 mg/L) is most effective at reducing oxidative stress and lung cell DNA damage without causing further harm.
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The health benefit of a vegetarian diet is still under debate as it may result in a higher intake of some beneficial micronutrients, while others may be reduced, thus influencing various metabolic pathways and health-related biomarkers. This scoping review discusses inflammatory, oxidative and DNA damage status in vegetarians and vegans compared to omnivores. Most of the reviewed studies indicated favorable effects of a vegetarian diet on oxidative status compared to omnivores but did not clearly associate particular dietary habits to genome damage.

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Fructose (CHO), also known as levulose, is a hexose. Chronic consumption of fructose may be associated with increased intrahepatic fat concentration and the development of insulin resistance as well as an increase in the prevalence of nonalcoholic fatty liver disease and hyperlipidemia during pregnancy. Despite the existence of many studies regarding the consumption of fructose in pregnancy, its effects on fetuses have not yet been fully elucidated.

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  • Obesity is linked to various diseases, and the study investigates the effects of Zingiber officinale (ZO), a potential natural treatment, on diet-induced obesity in mice. !* -
  • Mice subjected to a high-fat diet developed insulin resistance and inflammation, but ZO supplementation improved insulin sensitivity, reduced certain inflammatory markers, and decreased oxidative stress without altering body weight. !* -
  • The findings suggest that ZO could serve as a complementary treatment for obesity, enhancing antioxidant defenses and reducing damage in tissues affected by obesity-related conditions. !*
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The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental systems. These differences may be attributed to protocol differences, although it is difficult to identify the relevant conditions because detailed comet assay procedures are not always published.

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The Brazil nut () originating from the Amazon region is one of the richest known sources of selenium (Se), a micronutrient that is essential and required for optimal physiological functioning. This mineral presents several health benefits, including improvement of the redox cellular status and maintenance of genomic stability. Knowing that type 2 diabetes mellitus (T2D) is strongly linked to oxidative stress and consequently DNA damage, the aim of this study was to assess the antioxidative effects of Se through Brazil nut consumption and its potential in preventing oxidative DNA damage induced by HO.

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  • The ageing process leads to reduced cellular functions and more degenerative diseases, with decreased melatonin production as we age.
  • This study examined how chronic melatonin consumption affects DNA damage and genetic stability in older Swiss mice by providing supplementation starting at various ages.
  • Findings revealed that melatonin not only extended the lifespan of the mice but also reduced age-related DNA damage and boosted repair enzyme levels, highlighting its potential as an effective antioxidant against age-related changes.
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  • Cells often suffer from DNA damage which can lead to serious issues like neuronal death and contribute to neurological disorders, cancer, and aging.
  • Engaging in physical exercise has been shown to protect the brain, enhancing cognition and memory while regulating oxidative stress and reducing DNA damage.
  • The review highlights various studies exploring how exercise influences DNA repair in the brain, but the specific neuroplasticity molecules involved in this process are still not fully understood.
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  • - Melanoma is a serious skin cancer that can spread to various organs, leading to DNA damage, while melatonin is a hormone known to protect DNA and inhibit the growth of melanoma cells.
  • - The study involved 32 male mice divided into four groups to investigate the impact of melatonin on B16F10 melanoma, focusing on DNA damage and tumor size after 60 days of treatment.
  • - Results showed that melatonin supplementation reduced DNA damage in several tissues, highlighting its potential as an anti-tumor agent, although its effects on lung DNA damage were not conclusive.
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The consumption of fructose during pregnancy can cause hyperglycaemia and may stimulate production of reactive oxygen species; however, there are only a few studies reporting whether fructose consumption during pregnancy causes DNA damage. Therefore, the aim of this study was to evaluate the effects of fructose consumption on genetic and biochemical parameters in Swiss mice treated during pregnancy and lactation. For this, 15 couples of 60-day-old Swiss mice were divided into three groups of five couples: negative control (water) and two fructose groups (fructose dose of 10%/l and 20%/l).

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Antineoplastic therapy has been associated with pain syndrome development characterized by acute and chronic pain. The chemotherapeutic agent dacarbazine, used mainly to treat metastatic melanoma, is reported to cause painful symptoms, compromising patient quality of life. Evidence has proposed that transient receptor potential ankyrin 1 (TRPA1) plays a critical role in chemotherapy-induced pain syndrome.

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Sprengel, popularly known as "guaco," is used in Brazilian folk medicine for several inflammatory and allergic conditions. Besides, the popular use "guaco" is indicated by the Brazilian Ministry of Health as a safe and effective herbal medicine. The biological activity of extracts is due to the presence of the coumarins, a large family of phenolic substances found in plants and is made of fused benzene and α-pyrone rings.

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Copaifera officinalis L. possesses traditional uses as an analgesic, anti-inflammatory, and antiseptic. However, until now the antinociceptive effect and the mechanism of action were not described for Copaifera officinalis L.

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Neuropathic pain is a common type of chronic pain caused by trauma or chemotherapy. However, this type of pain is undertreated. TsNTxP is a non-toxic protein isolated from the venom of the scorpion Tityus serrulatus, and it is structurally similar to neurotoxins that interact with voltage-gated sodium channels.

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Type 2 diabetes mellitus has undergone a worldwide growth in incidence in the world and has now acquired epidemic status. There is a strong link between type 2 diabetes and vitamin D deficiency. Because vitamin D has beneficial effects on glucose homeostasis, the aim of this study was to evaluate the influence of vitamin D3 supplementation on the modulation of glycaemic control and other metabolic effects, as well as modulation of genomic instability in patients with type 2 diabetes.

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Caffeine is a bioactive compound worldwide consumed with effect into the brain. Part of its action in reducing incidence or delaying Alzheimer's and Parkinson's diseases symptoms in human is credited to the adenosine receptors properties. However, the impact of caffeine consumption during aging on survival of brain cells remains debatable.

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