Publications by authors named "Vanessa Mhana"
Article Synopsis
- B lymphocytes in teleost fish, like rainbow trout, exhibit clonal responses to infections, primarily in the pronephros, which serves as their main site for B cell differentiation and plasma cell persistence.
- The study utilized barcoded 5' RACE-cDNA sequencing to analyze changes in the IgHμ repertoire after immunization with the viral hemorrhagic septicemia virus (VHSV), revealing extensive modifications and VH subgroup involvement following primary infection.
- Interestingly, after a booster dose, there was a decrease in the frequency of anti-VHSV clonotypes in both the pronephros and spleen, highlighting the need for a deeper understanding of B cell circulation and memory formation in fish.
