Phenotypic implications of a co-existent haemorrhagic and thrombotic genotype.

Inherited bleeding disorders such as Von Willebrands disease (VWD) present with varying bleeding tendencies in different individuals. There have been several attempts to identify the determinants for this varying severity of the haemorrhagic manifestations, especially in those with milder forms or type 1 VWD. Genetic mutations have been noted in persons with haemophilia to be contributing to a milder bleeding phenotype.

Successful management of recurrent pregnancy-related thrombotic thrombocytopaenia purpura in a renal transplant recipient.

Thrombotic thrombocytopaenic purpura (TTP) is a rare but potentially devastating complication of pregnancy. We report the first documented case of a successful treatment of recurrent TTP complicating pregnancy in a renal transplant patient.

Multisystem failure due to three coexisting autoimmune diseases.

Systemic lupus erythematosis (SLE) is a potentially fatal, autoimmune disease, which can affect different organs and can present with protean clinical manifestations. It may be associated with many other autoimmune conditions and two rare such conditions are myelofibrosis and acquired haemophilia. Autoimmune myelofibrosis is a bone marrow disorder characterized by pancytopenia, which can occur in conjunction with the presenting features, or an exacerbation of previously established SLE.

Immune restoration disease in HIV patient.

We describe a severely immunosuppressed HIV-1-positive man in whom immune restoration disease associated with pulmonary infection caused by Mycobacterium microti developed after antiretroviral treatment. The diagnosis was made by using convenient spoligotyping techniques, but invasive investigations were required to exclude a tumor.

How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review.

Objective: To determine whether inherited and acquired thrombophilias are associated with adverse obstetric complications.

Study Design: A systematic review; studies where women with adverse obstetric complications were tested for one or more acquired and inherited thrombophilias were included.

Main Outcome Measures: Prevalence of thrombophilia in women with severe pre-eclampsia/eclampsia, severe placental abruption, intrauterine growth restriction or unexplained stillbirth.