Kisspeptin is a peptide linked to reproductive development and is produced by the KiSS-1 gene, with levels being significantly higher during normal pregnancies compared to nonpregnant women.
A study measured kisspeptin levels in patients with malignant gestational trophoblastic neoplasia (GTN) and found elevated levels before chemotherapy, which decreased following treatment.
Plasma kisspeptin levels were strongly correlated with human chorionic gonadotropin (hCG) levels, indicating that kisspeptin could serve as a potential tumor marker in malignant GTN cases.