Publications by authors named "Vanessa Lythe"
Article Synopsis
- Anterior cruciate ligament (ACL) injuries in the knee often lead to decreased activity levels and a higher risk of osteoarthritis, and there’s a lack of clear guidelines for managing these injuries either through surgery or rehabilitation.
- This study aimed to compare the effectiveness and cost of surgical ACL reconstruction without prior rehab against a rehabilitation approach before surgery for patients with non-acute ACL injuries and symptoms of instability.
- Conducted across 29 NHS orthopedic units in the UK, the trial tracked key outcomes like knee function and patient satisfaction over 18 months in 316 participants.
Article Synopsis
- Anterior cruciate ligament (ACL) ruptures can severely affect knee stability, leading researchers to compare reconstructive surgery and non-surgical rehabilitation in patients with persistent instability symptoms.
- A randomized controlled trial involved 316 patients across 29 UK NHS orthopedic units, with participants split into surgical and rehabilitation groups, primarily assessing outcomes using the Knee Injury and Osteoarthritis Outcome Score-4 at 18 months.
- Results showed that the surgical group had a higher average KOOS4 score (73.0) compared to the rehabilitation group (64.6), indicating that surgery may be more effective; however, many patients in the rehabilitation group later opted for surgery.
Objective: This study was undertaken to compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and noncarriers with and without subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease.
Methods: Clinical and genetic data from 12 datasets were examined. Global cognition was assessed using the Mattis Dementia Rating Scale (MDRS).
Objectives: Minimally conscious state (MCS) is a disorder of consciousness in which minimal but definite behavioral evidence of self-awareness or environmental awareness is demonstrated. Deep brain stimulation (DBS) of various targets has been used to promote recovery in patients with disorders of consciousness with varying results. The aim of this systematic review was to assess the effects of DBS in MCS following traumatic brain injury (TBI).
View Article and Find Full Text PDFBackground: Recent evidence suggests that glucosidase beta acid (GBA) mutations predispose Parkinson's disease (PD) patients to a greater burden of cognitive impairment and non-motor symptoms. This emerging knowledge has not yet been considered in patients who have undergone deep brain stimulation (DBS); a surgery that is generally contraindicated in those with cognitive deficits.
Objective: To explore the long-term phenotypic progression of GBA-associated PD, in a DBS cohort.