Publications by authors named "Vanessa L Oliver"
Available methods for recognizing and assessing pain in rodents have increased over the last 10 years, including the development of validated pain assessment scales. Much of this work has been driven by the needs of biomedical research, and there are specific challenges to applying these scales in the clinical environment. This article provides an introduction to pain assessment scale validation, reviews current methods of pain assessment, highlighting their strengths and weaknesses, and makes recommendations for assessing pain in a clinical environment.
View Article and Find Full Text PDFUsing Cageside Measures to Evaluate Analgesic Efficacy in Mice () after Surgery.
J Am Assoc Lab Anim Sci
March 2018
Recent studies have revealed some of the most frequently used analgesics in mice are not effectively treating postoperative pain. Our laboratory sought to compare and assess the validity and reliability of 2 cageside pain assessments that we recently developed for use in mice-nesting consolidation and grooming transfer tests. We then applied these tests to compare the efficacy of commonly used analgesics-buprenorphine (0.
View Article and Find Full Text PDFArticle Synopsis
- Guinea pigs are often used in research, necessitating effective pain relief methods due to potentially painful procedures.
- The study assessed the effectiveness of carprofen, extended-release buprenorphine, and their combination for managing postsurgical pain, revealing that multimodal analgesia offered better pain control.
- It was found that multimodal analgesia limited pain sensitivity and behavior for a shorter time than single analgesics, but weight loss in buprenorphine-treated animals indicates the need for careful analgesia selection.