Publications by authors named "Vanessa L Lau"
Article Synopsis
- Known genetic risk factors account for about one-third of familial endometrial cancer cases, but the link between rare germline copy number variants (CNVs) and cancer risk is not well understood.
- A study analyzed DNA from over 4,000 endometrial cancer patients and nearly 18,000 controls, finding that the cancer group had a significantly higher number of CNVs.
- The research identified 141 gene loci potentially related to endometrial cancer risk, highlighting a specific area (16p11.2) with recurrent deletions that could help further investigations into genetic susceptibility.
Sentinel lymph node (SLN) biopsy is the standard axillary staging procedure of early breast cancer. Superparamagnetic iron oxide (SPIO) nanoparticles have been found to be comparable to, while overcoming many of the limitations associated with, the current standard of care for SLN biopsies (dual localisation with radioisotope and patent blue dye). Here, SPIO dual localisation (Sienna+® and blue dye) is compared to blue dye alone for SLN biopsies in a rural centre where radioisotope techniques are not readily available.
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