Increased antinuclear (anti-Sm) antibodies in infertile patients with peritoneal endometriosis.

Objective: The aim of this study is to evaluate the intensity of five antibodies against extractable nuclear antigens (ENA: RNP, ScL-70, SS-B, SS-A, and Sm) in infertile patients with endometriosis.

Methods: We investigated infertile women with minimal/mild endometriosis (n=43) and fertile women (n=46).

Results: The intensity of immunoreactions was also similar for anti-RNP and anti-SS-A antibodies.

Transforming growth factor beta-1 (TGF-β1) expression in patients with adenomyosis.

Objective: To compare Transforming growth factor beta-1 (TGF-β1) expression in patients with and without adenomyosis.

Methods: A prospective design was performed including 49 patients submitted to hysterectomy. Immunohistochemistry was performed on anatomopathological samples staged in paraffin blocks from patients with and without adenomyosis.

A Brazilian cohort of pregnant women with overt diabetes: analyses of risk factors using a machine learning technique.

Objective: Pregnancy complicated by type 2 diabetes is rising, while data on type 2 diabetes first diagnosed in pregnancy (overt diabetes) are scarce. We aimed to describe the frequency and characteristics of pregnant women with overt diabetes, compare them to those with known pregestational diabetes, and evaluate the potential predictors for the diagnosis of overt diabetes.

Subjects And Methods: A retrospective cohort study including all pregnant women with type 2 diabetes evaluated in two public hospitals in Porto Alegre, Brazil, from May 20, 2005, to June 30, 2021.

Exploring the Gantt chart as a tool to highlight double report in case series published during the first wave of the COVID-19 pandemic.

Background: During the COVID-19 pandemic, some studies describing different aspects of the infection included very similar participants, rising suspicion about double reporting. We aimed to evaluate the Gantt chart as a tool to highlight possible double reporting. The chart is routinely used in business applications to depict tasks of a project, by plotting horizontal bars against time, showing their time span and overlaps.

p63 expression in granulosa-luteinized cells of infertile patients with peritoneal endometriosis submitted to in vitro fertilization.

Objective: Endometriosis is associated with infertility, even without an anatomical abnormality. Furthermore, the peritoneal (mild) phenotype of this disease is the most prevalent and linked to infertility. The present study aimed to investigate the p63 gene and protein expression in granulosa cells from pre-ovulatory follicles in patients with endometriosis and infertility submitted to in vitro fertilization.

A snapshot of the prevalence of endocrine disorders in pregnancies complicated by coronavirus disease 2019: A narrative review with meta-analysis.

Background: Some maternal characteristics indicate worse prognosis in pregnant women with coronavirus disease 2019 (COVID-19).

Objective: To describe the prevalence of endocrine disorders in pregnancies involving COVID-19, and its impact on maternal outcomes.

Search Strategy: Search terms were "pregnancy" and "COVID-19".

The Graduated Embryo Score of Embryos from Infertile Women with and without Peritoneal Endometriosis.

Objective:  To determine embryo quality (mean graduated embryo score [GES]) in infertile patients with endometriosis undergoing in vitro fertilization with embryo transfer (IVF-ET) compared with infertile patients without endometriosis.

Methods:  A case-control study was performed comparing 706 embryos (162 patients) divided into 2 groups: 472 embryos derived from patients without endometriosis ( = 109, infertile patients with tubal infertility) and 234 embryos from patients in the study group ( = 53, infertile patients with peritoneal endometriosis). All patients were subjected to IVF using an oestradiol-antagonist-recombinant follicle-stimulating hormone (FSH) protocol for ovarian stimulation.

Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist.

Objective: The aim of the present study is to investigate embryo quality (score) after controlled ovarian stimulation for IVF using rFSH or hMG with the GnRH antagonist protocol.

Methods: Open, randomized, single center study. The patients were randomized to receive rFSH or hMG according to randomized cards inside a black envelope with the name of the respective treatment following a computer generated list (85 patients were allocated to rFSH group and 83 patients to hMG group).

PIWIL2 is overexpressed in adenomyotic lesions of women with diffuse adenomyosis.

Purpose: Adenomyosis has been studied throughout the years, however, its aetiology and physiopathology are still unknown. The aim of this study was to identify the presence of PIWI proteins in women with adenomyosis.

Methods: We included 72 participants to be part of this study and were divided into two groups based on their anatomopathological diagnosis, control (n = 36) or adenomyosis (n = 36).

Diclofenac versus a combination of hyoscine and diclofenac for outpatient hysteroscopy: A placebo controlled randomized clinical trial.

Objective: to compare the effect of administering diclofenac sodium and/or oral hyoscine in pain perception during and after outpatient diagnostic hysteroscopy without anesthesia.

Study Design: a randomized, double-blind placebo-controlled clinical trial was performed in an University Hospital. We included 217 patients submitted to office hysteroscopy for the following indications: diagnosis of abnormal uterine bleeding, endometrial polyps, submucous myomas, infertility and recurrent miscarriage.

Correlations among algometry, the visual analogue scale, and the numeric rating scale to assess chronic pelvic pain in women.

Objective: To investigate the correlation between the numerical rating scale, visual analogue scale, and pressure threshold by algometry in women with chronic pelvic pain.

Study Design: This was a cross-sectional study. We included 47 patients with chronic pelvic pain.

Alterations in expression of endometrial milk fat globule-EGF factor 8 (MFG-E8) and leukemia inhibitory factor (LIF) in patients with infertility and endometriosis.

Objective: The aim of this study was to compare the endometrial expression of milk fat globule-EGF factor 8 (MFG-E8), its receptor integrin αvβ3, and leukemia inhibitory factor (LIF) in patients with endometriosis and infertility and in healthy fertile patients during the window of implantation.

Methods: Five patients with peritoneal endometriosis and infertility (case group) and four healthy fertile patients (control group) were recruited. All patients were either diagnosed with or ruled out for endometriosis by laparoscopic surgery; the case group underwent surgery for infertility investigation and the control group for tubal ligation.

Endometriosis-associated infertility: GDF-9, AMH, and AMHR2 genes polymorphisms.

Purpose: The purpose of this paper is to determine whether there is a correlation between polymorphisms in the growth differentiation factor-9 (GDF-9) gene and anti-Müllerian hormone (AMH) gene and its receptor, AMHR2, and endometriosis-associated infertility.

Methods: This is a case-control study to evaluate whether there is a correlation between polymorphisms in the GDF-9 gene (SNPs determined by direct sequencing), AMH gene, AMHR2 (both SNPs determined by genotyping using TaqMan Allelic Discrimination), and endometriosis-associated infertility. The study included 74 infertile women with endometriosis and 70 fertile women (tubal ligation) as a control group.

A prospective study comparing two embryo-transfer soft catheters.

Objectives: To compare reproductive outcomes using two different soft catheters i.e. Set TDT® and Cook® Sydney IVF.

LH (Trp8Arg/Ile15Thr), LHR (insLQ) and FSHR (Asn680Ser) polymorphisms genotypic prevalence in women with endometriosis and infertility.

Purpose: To verify if polymorphisms of LH (Trp8Arg/Ile15Thr), LH receptor (insLQ), and FSH receptor (Asn680Ser) are associated with endometriosis and infertility.

Methods: This is a prospective case-control study. Sixty-seven patients with endometriosis and infertility (study group) and 65 healthy fertile patients (control group) were enrolled in the study between July 2010 and July 2013.

AMH as a Prognostic Factor for Blastocyst Development.

Objective: To investigate the relationship between AMH blood levels and the likelihood of blastocyst formation.

Methods: Two hundred ninety-two patients, 22-44 years of age, undergoing routine explorations during spontaneous cycles that preceded assisted reproductive technologies at our Center, were studied. As the present study did not require previous submission to our Institutional Review Board.

Dopamine receptor D2 genotype (3438) is associated with moderate/severe endometriosis in infertile women in Brazil.

Objective: To compare the prevalence of dopamine receptor D2 polymorphisms in patients with peritoneal endometriosis and in healthy control subjects.

Design: Case-control study.

Setting: University hospital.

Frequent polymorphisms of FSH receptor do not influence antral follicle responsiveness to follicle-stimulating hormone administration as assessed by the Follicular Output RaTe (FORT).

Purpose: To verify whether carriers of common single-nucleotide polymorphisms (SNPs) of the FSH receptor (FSHR) show reduced responsiveness of antral follicles to FSH administration as assessed by the FORT.

Methods: We performed a prospective study in a university hospital. Study population consisted of 124 Caucasian IVF-ET candidates.

Baropodometry on women suffering from chronic pelvic pain--a cross-sectional study.

Background: Previous studies have associated chronic pelvic pain with a stereotyped pattern of movement and posture, lack of normal body sensations, a characteristic pain distribution. We aimed at evaluating if these postural changes are detectable in baropodometry results in patients with chronic pelvic pain.

Methods: We performed a prospective study in a university hospital.

Office hysteroscopy study in consecutive miscarriage patients.

Objective: To assess the prevalence of uterine anatomical abnormalities found by office diagnostic hysteroscopy in a population of patients experiencing more than two consecutive miscarriages and compare the prevalence of uterine abnormalities between patients with two miscarriages and those with three or more consecutive miscarriages.

Methods: A cross-sectional study of 66 patients with two or more consecutive miscarriages diagnosis was conducted. Patients were divided into two groups: Group A (up to two miscarriages, 23 patients), and Group B (3 miscarriages, 43 patients).

Quality of life associated to chronic pelvic pain is independent of endometriosis diagnosis--a cross-sectional survey.

Background: Pain is strongly related to poor quality of life. We performed a cross-sectional study in a university hospital to investigate quality of life in women suffering from chronic pelvic pain (CPP) due to endometriosis and others conditions.

Methods: Fifty-seven patients aged between 25 and 48 years-old submitted to laparoscopy because of CPP were evaluated for quality of life and depressive symptoms.

T helper (Th)1, Th2, and Th17 interleukin pathways in infertile patients with minimal/mild endometriosis.

In the present study, interleukin (IL)-10, IL-12, IL-17, and IL-23 levels were measured in serum and peritoneal fluid of women with minimal or mild endometriosis and compared with levels in controls without endometriosis. Higher IL-23 levels were encountered in the peritoneal fluid of women with endometriosis, suggesting a possible role of this cytokine in these women's infertility.

There is no complete linkage between the polymorphisms N680S and T307A of the follicular stimulating hormone receptor gene in fertile women.

Purpose: We conducted a cross-sectional study to evaluate the linkage of FSHR T307A and N680S in a group of fertile women.

Methods: Peripheral blood was obtained from 51 fertile women. DNA extraction and isolation were performed.

References to alcohol consumption and alcoholism in medical records of a general hospital of Porto Alegre, Brazil--a comparison between samples with a 20 year gap.

Two samples of inpatients (493 and 158 subjects, respectively) of a large teaching hospital, collected using the same methodology and with a 20-year time frame, were analyzed aiming at finding information about alcohol consumption, abuse or dependence in the subjects' medical charts. Items reviewed were: the list of medical problems; hospital intake form; daily nursing review; medical anamnesis; pre-surgery records, and discharge forms. Only 54% and 50% of each sample, respectively, had some type of reference to alcohol consumption; when references were present, they were in most part incomplete, possibly reflecting distortions in the process of gathering information about alcohol consumption that involves the client and the health professionals.