Current kidney disease treatments often lack specificity and can be toxic to the whole body.
A human monoclonal antibody called F1.1 targets a specific part of a collagen protein found in the kidneys, making it a good candidate for delivering treatments directly to damaged areas.
Experiments showed that when drugs like PGE2 and dexamethasone were linked to F1.1 and given to mice with kidney inflammation, they improved recovery and reduced side effects, suggesting a promising new approach for targeted kidney therapies.