Fiber-based lactate recordings with fluorescence resonance energy transfer sensors by applying an magnetic resonance-informed correction of hemodynamic artifacts.

Fluorescence resonance energy transfer (FRET) sensors offer enormous benefits when studying neurophysiology through confocal microscopy. Yet, their use for fiber-based recordings is hampered by massive confounding effects and has therefore been scarcely reported. We aim to investigate whether fiber-based lactate recordings in the rodent brain are feasible with FRET sensors and implement a correction algorithm for the predominant hemodynamic artifact.

Fingerprints of Element Concentrations in Infective Endocarditis Obtained by Mass Spectrometric Imaging and t-Distributed Stochastic Neighbor Embedding.

-induced infective endocarditis (IE) is a life-threatening disease. Differences in virulence between distinct strains, which are partly based on the molecular mechanisms during bacterial adhesion, are not fully understood. Yet, distinct molecular or elemental patterns, occurring during specific steps in the adhesion process, may help to identify novel targets for accelerated diagnosis or improved treatment.

Host-pathogen interactions of clinical isolates to induce infective endocarditis.

To evaluate potential pathomechanisms in the induction of infective endocarditis (IE), 34 () isolates, collected from patients with endocarditis and from healthy individuals were investigated both and isolates were tested for their cytotoxicity, invasion and the association with platelets. Virulence factor expression profiles and cellular response were additionally investigated and tested for correlation with the ability of to induce vegetations on the aortic valves . In an animal model of IE valvular conspicuity was assessed by magnetic resonance imaging at 9.