Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study.

Background: The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact on discomfort of ICU patients.

Methods: This randomized multicenter non-inferiority open trial included patients admitted in intensive care unit and receiving oxygen.