Validation of Selective Capture of Fimbriated Uropathogenic by a Label-free Engineering Detection System Using Mannosylated Surfaces.

Label-free detection of pathogens is of major concern to the microbiologist community. Most procedures require several steps and amplification techniques. Carbohydrates are well-established receptors for host-pathogen interactions, which can be amplified using glycodendritic architectures on the basis of multivalent binding interactions.

Surface Grafted MSI-78A Antimicrobial Peptide has High Potential for Gastric Infection Management.

As we approach the end of the antibiotic era, newer therapeutic options, such as antimicrobial peptides (AMPs), are in urgent demand. AMP surface grafting onto biomaterials has been described as a good strategy to overcome problems associated with their in vivo stability. Helicobacter pylori is among the bacteria that pose greatest threat to human health, being MSI-78A one of the few bactericidal AMPs against this bacterium.

Vitamin B metal-organic frameworks as potential delivery vehicles for therapeutic nitric oxide.

The synthesis and structural characterization of two isostructural metal (M=Ni, Co) 3D framework structure that integrate vitamin B building blocks with NO delivery capabilities and low toxicity is presented. The compounds with a formula [M(μ-HO)(μ-vitamin B)]·2HO contain two crystallographic distinct divalent metal centres connected by a bridging water and carboxylate group from vitamin B. The porous compounds have the capability of storing and releasing nitric oxide (NO) in a slow and reversible manner, with released amounts of 2.