Altered expression of COX-2 and TNF-α in patients with hepatocellular carcinoma.

Background And Aim: hepatocellular carcinoma is a type of cancer related with inflammation, as 90% of cases develop in a chronic inflammation condition. Excess inflammation can affect tissue homeostasis. Cytokines and inflammatory mediators are immunological components that can influence the functioning of cells and tissues.

Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma.

Introduction: Considering the high prevalence of liver tumors and the impact on patient survival, a greater understanding of the biological behavior of those tumors if of great importance. The multidrug resistance gene (MDR1) may present as single nucleotide polymorphism (SNP) which can affect the expression and activity of P-glycoprotein (Pgp), and high expression of Pgp has been associated with a worse prognosis in affected patients.

Objective: To correlate the C3435T polymorphism in the MDR1 gene with the immunohistochemical expression of Pgp.