Publications by authors named "Vanessa Camara Fernandes"
Article Synopsis
- - The CYP2C19 gene is key for drug metabolism and exhibits high variability, influencing how drugs like escitalopram are processed in different populations, particularly in Native Americans.
- - Research shows that certain genetic variants (haplotypes) linked to CYP2C19 can cause discrepancies in expected drug metabolism rates, with a specific haplotype being more common in Native American groups than in other populations.
- - The study indicates that these genetic variations may explain differences between predicted metabolizing abilities and actual drug processing observed in Native American cohorts, highlighting the need for further research on this haplotype's effects.
Article Synopsis
- - Carbamazepine can cause skin hypersensitivity reactions linked to certain human leukocyte antigens (HLAs), and previous studies have identified specific genetic variants (rs1061235 and rs17179220) with predictive potential for these reactions in various populations.
- - The research examined how well these genetic variants serve as predictive markers in diverse groups of individuals with Native American ancestry, which are often overlooked in pharmacogenomic research.
- - The findings showed that while these variants performed well in some populations, they aren't consistently reliable across all Native American groups, indicating they may not be the best proxies for predicting adverse reactions to carbamazepine.
A murine model of venom-induced myotoxicity was used to assess the antimyotoxic capacity of a polyvalent antivenom (PAV), rich in F(ab')2 fragments, obtained from horses immunized with Bitis venoms. Intramuscular (i.m.
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