Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence.

Background: Inhibitory control develops in early childhood, and atypical development may be a measurable marker of risk for the later development of psychosis. Additionally, inhibitory control may be a target for intervention.

Methods: Behavioral performance on a developmentally appropriate Go/No-Go task including a frustration manipulation completed by children ages 3-5 years (early childhood; = 107) was examined in relation to psychotic-like experiences (PLEs; 'tween'; ages 9-12), internalizing symptoms, and externalizing symptoms self-reported at long-term follow-up (pre-adolescence; ages 8-11).

History of trauma is a critical treatment target for individuals at clinical high-risk for psychosis.

People meeting criteria for a clinical high-risk (CHR) for psychosis syndrome frequently represent a heterogeneous, help-seeking, and dynamic population. Among the numerous symptoms and risk factors for psychosis, exposure to trauma stands out as both highly prevalent and poorly understood. Indeed, while up to 80% of individuals meeting criteria for a CHR syndrome report trauma histories, there is currently limited research dedicated to this specific area.

Heart Rate Variability in Healthy Subjects During Monitored, Short-Term Stress Followed by 24-hour Cardiac Monitoring.

Heart Rate Variability (HRV) can be a useful metric to capture meaningful information about heart function. One of the non-linear indices used to analyze HRV, Detrended Fluctuation Analysis (DFA), finds short and long-term correlations in RR intervals to capture quantitative information about variability. This study focuses on the impact of visual and mental stimulation on HRV as expressed DFA within healthy adults.

Contributions of Arousal, Attention, Distinctiveness, and Semantic Relatedness to Enhanced Emotional Memory: An Event-Related Potential and Electrocardiogram Study.

Enhanced emotional memory (EEM) describes memory benefits for emotional items, traditionally attributed to impacts of arousal at encoding; however, attention, semantic relatedness, and distinctiveness likely also contribute in various ways. The current study manipulated arousal, semantic relatedness, and distinctiveness while recording changes in event-related potentials and heart rate during memory encoding. Trials were classified as remembered or forgotten by immediate recall performance.

One-Year Stability of Frontoparietal Cognitive Control Network Connectivity in Recent Onset Schizophrenia: A Task-Related 3T fMRI Study.

Kraepelinian theory posits that schizophrenia (SZ) is a degenerative disorder that worsens throughout the lifespan. Behavioral studies of cognition have since challenged that viewpoint, particularly in the early phases of illness. Nonetheless, the extent to which cognition remains functionally stable during the early course of illness is unclear, particularly with regard to task-associated connectivity in cognition-related brain networks.