Publications by authors named "Vanessa C Fernandes"
Article Synopsis
- - The CYP2C19 gene is key for drug metabolism and exhibits high variability, influencing how drugs like escitalopram are processed in different populations, particularly in Native Americans.
- - Research shows that certain genetic variants (haplotypes) linked to CYP2C19 can cause discrepancies in expected drug metabolism rates, with a specific haplotype being more common in Native American groups than in other populations.
- - The study indicates that these genetic variations may explain differences between predicted metabolizing abilities and actual drug processing observed in Native American cohorts, highlighting the need for further research on this haplotype's effects.
BRCA1 (Breast Cancer 1, early onset) is linked to breast and ovarian cancer predisposition. Still, the risks conferred by a significant portion of BRCA1 variants identified in the population remains unknown. Most of these variants of uncertain significance are missense alterations.
View Article and Find Full Text PDFArticle Synopsis
- - Carbamazepine can cause skin hypersensitivity reactions linked to certain human leukocyte antigens (HLAs), and previous studies have identified specific genetic variants (rs1061235 and rs17179220) with predictive potential for these reactions in various populations.
- - The research examined how well these genetic variants serve as predictive markers in diverse groups of individuals with Native American ancestry, which are often overlooked in pharmacogenomic research.
- - The findings showed that while these variants performed well in some populations, they aren't consistently reliable across all Native American groups, indicating they may not be the best proxies for predicting adverse reactions to carbamazepine.
Genetic testing for , a DNA repair protein, can identify carriers of pathogenic variants associated with a substantially increased risk for breast and ovarian cancers. However, an association with increased risk is unclear for a large fraction of variants present in the human population. Most of these variants of uncertain clinical significance lead to amino acid changes in the BRCA1 protein.
View Article and Find Full Text PDFDouble strand break lesions, the most toxic type of DNA damage, are repaired primarily through 2 distinct pathways: homology-directed recombination (HR) and non-homologous end-joining (NHEJ). BRCA1 and 53BP1, 2 proteins containing the BRCT modular domain, play an important role in DNA damage response (DDR) by orchestrating the decision between HR and NHEJ, but the precise mechanisms regarding both pathways are not entirely understood. Previously, our group identified a putative interaction between BRCA1 and BARD1 (BRCA1-associated RING domain 1) and the cyclin-dependent kinase (CDK9).
View Article and Find Full Text PDFArticle Synopsis
- DNA damage repair (DDR) is how cells fix broken DNA, using two main methods: one that makes perfect repairs (HR) and another that can mess things up (non-homologous end-joining).
- Galectin-3 (GAL3) is important in cancer development and works with a protein called BARD1, which is connected to breast and ovarian cancer.
- When researchers removed GAL3 from certain human cells exposed to DNA damage, the cells took longer to respond and didn't properly stop the cell cycle, showing GAL3 is crucial for the repair process.
Dental caries is one of the most prevalent conditions in humans; the purpose of restorative dentistry is to recreate the anatomy of the affected tooth thus the use of fragments from natural teeth as an effective restorative method. A maxillary first premolar left was prepared for an inverted 4/5 crown due to involvement of the vestibular face, after prepared received an allogeneic collage with similar color and dimension. Follow-up after 12 months indicated a stable restoration.
View Article and Find Full Text PDFTabernaemontana catharinensis root bark ethanol extract, EB2 fraction and the MMV alkaloid (12-methoxy-4-methylvoachalotine) were evaluated for their antimicrobial activities. T. catharinensis ethanol extract was effective against both strains of the dermatophyte Trichophyton rubrum at concentrations of 2.
View Article and Find Full Text PDFA murine model of venom-induced myotoxicity was used to assess the antimyotoxic capacity of a polyvalent antivenom (PAV), rich in F(ab')2 fragments, obtained from horses immunized with Bitis venoms. Intramuscular (i.m.
View Article and Find Full Text PDFSeveral Brazilian plants have been utilized in folk medicine as active agents against various effects induced by snake venoms. The inhabitants of the Amazon region use, among others, the macerated bark of a plant popularly named "Pracaxi" (Pentaclethra macroloba Willd) to combat these effects. We report now the antihemorrhagic properties against snake venoms of the aqueous extract of Pentaclethra macroloba (EPema).
View Article and Find Full Text PDF