Publications by authors named "Vanessa B Silveira"
Correction to: Potential outbreak by herpesvirus in equines: detection, clinical, and genetic analysis of equid gammaherpesvirus 2 (EHV-2).
Braz J Microbiol
June 2023
Potential outbreak by herpesvirus in equines: detection, clinical, and genetic analysis of equid gammaherpesvirus 2 (EHV-2).
Braz J Microbiol
June 2023
Article Synopsis
- Equid herpesvirus (EHV) poses significant threats to horses, leading to neurological and respiratory issues as well as spontaneous abortions, which impact the equine industry economically.
- In a case study in Brazil, 11 foals died with respiratory and neurological symptoms, alongside abortions in mares, prompting investigation using clinical and laboratory exams.
- Results indicated the first confirmed outbreak of EHV-2 in Brazilian horses, highlighting its role in equine respiratory diseases and foal mortality, with EHV-2 DNA identified in one foal's serum.
The current COVID-19 pandemic has emphasized the vulnerability of communities living in the urban outskirts and informal settlements. The lack of reliable COVID-19 case data highlights the importance and application of wastewater-based epidemiology. This study aimed to monitor the COVID-19 trends in four vulnerable urban communities (slums and low-income neighborhoods) in metropolitan São Paulo by assessing the SARS-CoV-2 RNA viral load in wastewater.
View Article and Find Full Text PDFMost approved vaccines against COVID-19 have to be administered in a prime/boost regimen. We engineered a novel vaccine based on a chimeric human adenovirus 5 (hAdV5) vector. The vaccine (named CoroVaxG.
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- The study monitored Zika virus (ZIKV) in four healthy adults for up to 298 days post-symptoms, focusing on virus presence in different body fluids and immune response.
- The two male patients shed ZIKV for up to 158 days, with virus detected in sperm cells, indicating potential sexual transmission, yet one was able to conceive afterward.
- Genetic analysis showed changes in the virus over time and suggested separate strains in the reproductive and urinary systems, highlighting risks of long-term virus presence in the male reproductive system.
Yellow fever virus RNA is usually detected in blood of infected humans. We detected virus RNA in urine and semen samples from a convalescent patient. A complete virus genome was sequenced for an isolate from a urine sample.
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- Dengue nonstructural protein 1 (NS1) plays a key role in the dengue virus's ability to replicate and affects how the host's immune system responds.
- Researchers created four monoclonal antibodies targeting NS1 from dengue virus serotype 2, which helped identify three specific regions (or epitopes) on the protein.
- The findings include two sequences recognized by certain antibodies that also interacted with Zika virus, and one new sequence unique to dengue, potentially aiding in the development of diagnostic tests to distinguish between dengue and Zika infections.
Adjuvant-Mediated Epitope Specificity and Enhanced Neutralizing Activity of Antibodies Targeting Dengue Virus Envelope Protein.
Front Immunol
September 2017
The heat-labile toxins (LT) produced by enterotoxigenic display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including -generated non-toxic mutant forms, little is known about the capacity of these adjuvants to modulate the epitope specificity of antibodies directed against antigens. This study characterizes the role of LT and its non-toxic B subunit (LTB) in the modulation of antibody responses to a coadministered antigen, the dengue virus (DENV) envelope glycoprotein domain III (EDIII), which binds to surface receptors and mediates virus entry into host cells.
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