Publications by authors named "Vanessa B Dos Santos"

Herein, we report a KIO-catalyzed oxidative coupling of thiols to their corresponding disulfides in water, in a short time and at ambient temperature. The reaction has a broad scope and exhibits good functional group tolerance, resulting in the desired products in excellent yields. This approach allows the reuse of the reaction system in multiple cycles and scale-up.

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Background: Dysarthria is one of the most frequent communication disorders in patients with Multiple Sclerosis (MS), with an estimated prevalence of around 50%. However, it is unclear if there is a relationship between dysarthria and the severity or duration of the disease.

Objective: Describe the speech pattern in MS, correlate with clinical data, and compare with controls.

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Article Synopsis
  • The study investigates how speech is affected in patients with disorders of the basal ganglia (like Parkinson's disease) compared to those with cerebellar disorders (like spinocerebellar ataxia type 3).
  • It includes 20 patients with Parkinson's, 20 with SCA3, and 40 healthy controls, analyzing their speech through specific tasks.
  • Results show that SCA3 patients produced fewer syllables in monologs compared to controls, while PD patients had even lower syllable counts and phonation times, indicating that monolog tasks can effectively differentiate between these conditions and correlate with disease severity.
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Purpose: To assess the association between acute disease severity and 1-year quality of life in patients discharged after hospitalisation due to coronavirus disease 2019 (COVID-19).

Methods: We conducted a prospective cohort study nested in 5 randomised clinical trials between March 2020 and March 2022 at 84 sites in Brazil. Adult post-hospitalisation COVID-19 patients were followed for 1 year.

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Objective: To describe the speech pattern of patients with hereditary Spastic Paraplegia type 4 (SPG4) and correlated it with their clinical data.

Methods: Cross-sectional study was carried out in two university hospitals in Brazil. Two groups participated in the study: the case group (n = 28) with a confirmed genetic diagnosis for SPG4 and a control group (n = 17) matched for sex and age.

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Unlabelled: Although it is predominantly a muscular disease, impairments in the central nervous system in patients with facioscapulohumeral muscular dystrophy (FSHD) have been described in the literature.

Objective: To describe the cognitive profile of patients with FSHD and to correlate the impairments found with clinical variables and quality of life.

Methods: Cross-sectional and case-control study that evaluated FSHD patients using a series of cognitive assessments (Mini-Mental State Examination - MMSE, Montreal Cognitive Assessment - MoCA, verbal fluency with phonological restriction - FAS, categorical verbal fluency - FAS-cat, trail-making test - TMT, and Rey's Verbal Auditory Learning Test); a neurological severity scale (Gardner-Medwin-Walton - GMWS); and a quality of life measurement tool (Medical Outcomes Study 36-Item Short-Form Health Survey).

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