Publications by authors named "Vanesa Rojas"
Article Synopsis
- Pulmonary arterial hypertension (PAH) involves a loss of microvessels, and the study investigates how Wnt pathways influence angiogenesis in these vessels.
- * The research shows that healthy pulmonary microvascular endothelial cells (PMVECs) express higher levels of Wnt7a, which is crucial for forming new blood vessels; this expression is missing in PAH patients.
- * Results indicate that Wnt7a aids VEGF signaling, and its absence leads to inadequate angiogenic responses, suggesting that Wnt7a deficiency might play a role in the worsening of small vessel function in PAH.*
Eukaryotic genomes are especially vulnerable to DNA damage during the S phase of the cell cycle, when chromosomes must be duplicated. The stability of DNA replication forks is critical to achieve faithful chromosome replication and is severely compromised when forks encounter DNA lesions. To maintain genome integrity, replication forks need to be protected by the S-phase checkpoint and DNA insults must be repaired.
View Article and Find Full Text PDFThe yeast checkpoint kinases Mec1 and Rad53 are required for genomic stability in the presence of replicative stress. When replication forks stall, the stable maintenance of replisome components requires the ATR kinase Mec1/Ddc2 and the RecQ helicase Sgs1. It was unclear whether either Mec1 or Sgs1 action requires the checkpoint effector kinase, Rad53.
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