Publications by authors named "Vanesa Maria Guerrero Ruiz"
Article Synopsis
- Hypoxia plays a significant role in various diseases, affecting the body's immune and metabolic responses, particularly between cholesterol levels and interferon (IFN) activity.
- In monocytes, low oxygen levels (hypoxia) reduce cholesterol production while activating SREBP2, which impacts the expression of genes related to inflammation.
- When hypoxic monocytes are infected with the virus causing COVID-19, hypoxia increases the activation of key signaling pathways that worsen inflammation, highlighting a connection between low oxygen and severe inflammatory responses in COVID-19.
Previous studies towards reduced oxygen availability have mostly focused on changes in total mRNA expression, neglecting underlying transcriptional and post-transcriptional events. Therefore, we generated a comprehensive overview of hypoxia-induced changes in total mRNA expression, global de novo transcription, and mRNA stability in monocytic THP-1 cells. Since hypoxic episodes often persist for prolonged periods, we further compared the adaptation to acute and chronic hypoxia.
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