Publications by authors named "Vanesa Fridman"
Background: Monocyte activation is a driver of inflammation in the course of chronic HIV infection. Prostaglandin E2 (PGE2) is known to mediate anti-inflammatory effects, notably the inhibition of tumor necrosis factor- (TNF-) production by monocytes. We aim to investigate the effects of PGE2 on activation of monocytes in chronic HIV infection and the mechanisms through which PGE2 modulates their inflammatory signature.
View Article and Find Full Text PDFArticle Synopsis
- Strongyloides stercoralis is a parasite affecting 30-100 million people globally, typically treated with ivermectin, but long-term efficacy studies are lacking.
- A study in Buenos Aires followed 21 patients over several years to assess treatment response using various detection methods for the parasite and its DNA.
- Results revealed that larvae reappeared in many patients within 30 days of treatment, with persistent DNA detection in stool samples, indicating ivermectin may not completely eradicate the infection and suggesting it should be viewed as a chronic condition.
Unlabelled: Vitamin D has immunomodulating properties. The nuclear receptor for vitamin D is expressed in several immune cells, which convert 25-hydroxyvitamin D (25OHD) to the active form 1,25 hydroxyvitamin D [1,25(OH) D]. Under conditions of infection, 1,25(OH) D promotes production of cathelicidin (an antimicrobial peptide) in monocytes and activated macrophages.
View Article and Find Full Text PDF