Effectiveness of a therapeutic bath for pain relief in hospitalized children with respiratory conditions: Randomized controlled clinical trial.

Aim: To assess the effectiveness of a therapeutic bath combined with analgesic medication versus the use of analgesic medication alone in alleviating generalized acute pain in hospitalized children with respiratory conditions.

Methods: A randomized controlled clinical trial, with parallel groups, with children aged 28 days to 3 years who were hospitalized for respiratory conditions with associated pain. Participants were allocated into two groups: 40 children to a control group (CG), which received isolated analgesic medication at same time, and 40 children to an intervention group (IG), which received both a therapeutic bath and analgesic medication.

Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program.

Melatonin and glucocorticoids are key hormones in determining daily rhythmicity and modulating defense responses. In nocturnal animals, corticosterone peaks at light/dark transition,while melatonin peaks at the middle of the night in both nocturnal and diurnal animals. The crosstalk between adrenal and pineal glands under inflammatory conditions indicates that corticosterone potentiates nocturnal melatonin synthesis by reducing the activity of NFκB.