Mutations in histones dysregulate copper homeostasis leading to defect in Sec61 dependent protein translocation mechanism in Saccharomyces cerevisiae.

The translocation of proteins from the cytoplasm to the endoplasmic reticulum occurs via a conserved Sec61 protein channel. Previously, we reported that mutations in histones cause downregulation of a CUP1 copper metallothionein and copper exposure inhibits the activity of Sec61. However, the role of epigenetic dysregulation on the activity of channel is not clear.