The photodynamic activities of dimethyl 13-[2-(guanidinyl)ethylamino] chlorin e photosensitizers in A549 tumor.

Effective photosensitizers are particularly important factor in clinical photodynamic therapy (PDT). However, there is a scarcity of photosensitizers for simultaneous cancer photo-diagnosis and targeted PDT. Herein, two novel dimethyl 2-(guanidinyl)ethylamino chlorin e photosensitizers were synthesized and their efficacy in PDT in A549 tumor was investigated.