Publications by authors named "Van Tram Ta"
Between 2010 and 2014, four chikungunya and two Zika virus infections were identified among 8,105 febrile children in southern Vietnam. Zika viruses were linked to French Polynesian strains, chikungunya to Cambodian strains. Against a backdrop of endemic dengue transmission, chikungunya and Zika present an additional arboviral disease burden in Vietnam.
View Article and Find Full Text PDFBackground: Early prediction of severe dengue could significantly assist patient triage and case management.
Methods: We prospectively investigated 7563 children with ≤3 days of fever recruited in the outpatient departments of 6 hospitals in southern Vietnam between 2010 and 2013. The primary endpoint of interest was severe dengue (2009 World Health Organization Guidelines), and predefined risk variables were collected at the time of enrollment to enable prognostic model development.
Background: Dengue endangers billions of people in the tropical world, yet no therapeutic is currently available. In part, the severe manifestations of dengue reflect inflammatory processes affecting the vascular endothelium. In addition to lipid lowering, statins have pleiotropic effects that improve endothelial function, and epidemiological studies suggest that outcomes from a range of acute inflammatory syndromes are improved in patients already on statin therapy.
View Article and Find Full Text PDFArticle Synopsis
- Hypovolemic shock, specifically dengue shock syndrome (DSS), is a critical and common complication in dengue fever, especially in children.
- A study involving over 4,000 participants from Vietnam revealed significant genetic markers linked to DSS, identifying two important susceptibility loci.
- The research pinpointed the MICB gene on chromosome 6 and a variant within PLCE1 on chromosome 10, suggesting they may influence the risk of developing severe DSS in dengue patients.