Publications by authors named "Van T Le"

Secondary active transporters play a crucial role in cellular physiology by facilitating the movement of molecules across cell membranes. Identifying the functional classes of these transporters, particularly amino acid and peptide transporters, is essential for understanding their involvement in various physiological processes and disease pathways, including cancer. This study aims to develop a robust computational framework that integrates pre-trained protein language models and deep learning techniques to classify amino acid and peptide transporters within the secondary active transporter (SAT) family and predict their functional association with solute carrier (SLC) proteins.

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This study explores the synthesis, characterization, and photocatalytic properties of bismuth metal-organic framework (Bi-MOF) nanorods and their derivatives such as Ag/Bi-MOF and Ag/BiO. Bi-MOF nanorods exhibit significant photocatalytic activity under visible light, with the addition of silver (Ag) enhancing electron-hole pair separation and reducing their recombination. This leads to improved photocatalytic performance, particularly in the degradation of organic pollutants such as Rhodamine B (RhB) and Methylene Blue (MB).

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Article Synopsis
  • * The study introduces vesiMCNN, a new computational approach that combines pre-trained protein language models with a multi-window scanning CNN to identify vesicular transport proteins accurately.
  • * The model shows impressive results with an MCC of 0.558 and an AUC-ROC of 0.933, surpassing previous methods, and a new benchmark dataset has been created to support future research in this area.
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Mitochondrial carriers (MCs) are essential proteins that transport metabolites across mitochondrial membranes and play a critical role in cellular metabolism. ADP/ATP (adenosine diphosphate/adenosine triphosphate) is one of the most important carriers as it contributes to cellular energy production and is susceptible to the powerful toxin bongkrekic acid. This toxin has claimed several lives; for example, a recent foodborne outbreak in Taipei, Taiwan, has caused four deaths and sickened 30 people.

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Article Synopsis
  • * The study focused on the U-box type E3 ubiquitin ligase (PUB) gene in rice to assess its genetic and biological functions against biotic stress, using gene editing techniques to create specific mutations.
  • * Results showed that the gene-edited rice lines, which had a mutation leading to a significant change in their amino acid sequence, exhibited enhanced resistance to bacterial leaf blight, indicating a link between specific gene modifications and improved stress tolerance.
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Posterior interosseous nerve syndrome (PINs) is a rare nerve compression syndrome that affects the deep branch of the radial nerve in the supinator muscle region. In this article, we aimed to report a case of a 58-year-old male who had clinical symptoms, electromyographic, ultrasound, and MRI features suggestive of PINs due to compressing the arcade of Frohse. He subsequently underwent surgical correlation at our hospital, and the clinical symptoms were improved significantly.

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Background: Our study aims to evaluate the biliary anatomy variation according to the Varotti classification and its correlation with surgical outcomes for both donors and recipients undergoing living donor liver transplants (LDLTs).

Methods: A retrospective analysis of 150 LDLT cases performed at a single center in Vietnam with preoperative radiologic evaluations and intraoperative surgical assessments to identify biliary variant anatomy. Postoperative biliary complications were documented and analyzed.

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Introduction: Intrahepatic and extrahepatic lithiasis, a condition characterized by the presence of stones in the liver and bile ducts, is a common disease in Asia, particularly in East and Southeast Asia. We report a case with laparoscopic exploration of the common bile duct using a flexible cholangioscope and modified trans-common bile duct tunnel for hepatolithiasis combined with the dilated common bile duct.

Presentation Of Case: A 35-year-old male patient has had chronic epigastric and right upper quadrant pain.

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Objectives: The objective of this study was to characterize mental health issues among Vietnamese healthcare workers (HCWs) and to identify related factors.

Methods: A cross-sectional study was conducted with 990 HCWs in 2021. Their mental health status was measured using the Depression, Anxiety, and Stress Scale.

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The present study introduces FeO-coated lapatinib-labeled Sm nanoparticles (denoted as FeO@lapatinib-Sm) as a promising avenue for advancing breast cancer treatment. The radiolabeled nanoparticles combine various attributes, offering enhanced therapeutic precision. The integration of lapatinib confers therapeutic effects and targeted delivery.

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Background And Aim: Newcastle disease (ND) is a major viral disease of poultry worldwide. However, data on the molecular characterization of Newcastle disease virus (NDV) in Vietnam are limited. This study aimed to identify the molecular characteristics of NDV strains from the vaccinated chickens farmed in Northern Vietnam.

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The widespread application of triazole fungicides (TFs) in agricultural practices can result in the considerable accumulation of active compound residues in the soil and a subsequent negative impact on the soil microbiota and crop health. In this study, we isolated three TF-degrading bacterial strains from contaminated agricultural soils and identified them as sp., sp.

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The persistent presence of organic pollutants like dyes in water environment necessitates innovative approaches for efficient degradation. In this research, we developed an advanced hybrid catalyst by combining metal oxides (CuO, FeO) with UiO-66, serving as a heterogeneous Fenton catalyst for for efficient RB19 breakdown in water with HO. The control factors to the catalytic behavior were also quantified by machine learning.

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Article Synopsis
  • The study aimed to evaluate the sleep quality of healthcare workers (HCWs) in Vietnam during the COVID-19 pandemic, using the Pittsburgh Sleep Quality Index (PSQI), finding that 73.8% reported poor sleep quality.
  • Key factors linked to poor sleep included having chronic health conditions, being directly involved in patient care, working long hours, and frequently encountering critically ill patients.
  • The results highlight the need for improved working conditions for HCWs to enhance their sleep quality, reflecting similar findings from other countries during the pandemic.
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Introduction: The Vietnamese Home Falls and Accidents Screening Tool (HOME FAST) was developed to measure the number of home hazards present in the homes of older Vietnamese people and the risk of falls.

Methods: The HOME FAST and the HOME FAST manual were translated into Vietnamese by an independent translator and underwent backward translation by local health professionals into English to evaluate the accuracy of the translation. A panel of 14 Vietnamese health professionals evaluated the validity of the HOME FAST translation and rated the clarity and cultural relevance of each item.

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Objective: To evaluate the result of gamma knife radiosurgery (GKRS) for drug-resistant primary trigeminal neuralgia (TN).

Methods: Patients who were diagnosed with drug-resistant primary TN were treated with GKRS at the Nuclear Medicine and Oncology Center, Bach Mai Hospital from January 2015 to June 2020. Using the pain rating scale of the Barrow Neurological Institute (BNI), follow-ups and evaluations were conducted at 1 month, 3 months, 6 months, and 9 month, and 1, 2 years, 3 years, and 5 years after radiosurgery.

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Unlabelled: Evaluating the results of laparoscopic cholecystectomy (LC) using indocyanine green (ICG) fluorescence.

Materials And Methods: This is a cross-sectional study of patients with LC using real-time fluorescent ICG to treat gallbladder disease from May 2021 to May 2022 in the 108 Military Central Hospital.

Results: There were 68 patients who underwent LC using intraoperative ICG fluorescence for bile duct visualization.

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In this study, the kinetic degradation of several typical organic pollutants was performed on a synthetic electrode (Ti/SnO-Sb/Co-βPbO). The surface structure and the electrochemical properties of the prepared electrode were investigated, confirming the successful preparation of the electrode using an electrochemical deposition method. The outer layer (Co-βPbO) played an important role in reducing the resistance of the electrode and improving its degradation efficiency.

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Problem: Like most low- and middle-income countries, Viet Nam has a scarcity of rehabilitation professionals and lacks training programmes that meet international standards.

Approach: In 2018, four Vietnamese medical universities, the Université Catholique de Louvain, the Université Libre de Bruxelles, the Humanity & Inclusion charity and World Physiotherapy agreed to collaborate on strengthening pre-service education for physiotherapists in the country.

Local Setting: Viet Nam has a favourable environment for nurturing rehabilitation services and education: development funds have been available; government investment is increasing; and rehabilitation education has existed for many decades.

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Ninety-five percent of the general nutrients in rice are concentrated in the rice bran and germ, and many nutrients such as vitamins, minerals, dietary fiber, and essential fatty acids, as well as antioxidants such as tocopherol, are lost during milling. In this study, we investigated the thickness of seed coat and aleurone layers using a 294 rice core collection, and found candidate genes related to thickness of seed coat and aleurone layers, by performing a genome wide association study (GWAS) analysis using whole genome resequencing data. Two primer pairs that can be used as high-resolution melting (HRM) markers were developed.

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Article Synopsis
  • * Key synthesis conditions were optimized to achieve the best results, resulting in spherical AuNPs approximately 15 nm in size.
  • * The developed colorimetric assay was highly sensitive and selective, with a low detection limit for Pb ions, and showed effective performance in testing drinking water samples.
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An estimated 73% of emerging infections are zoonotic in origin, with animal contact and encroachment on their habitats increasing the risk of spill-over events. In Vietnam, close exposure to a wide range of animals and animal products can lead to acquisition of zoonotic pathogens, a number of which cause central nervous system (CNS) infections. However, studies show the aetiology of CNS infections remains unknown in around half of cases.

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Volatile organic compounds (VOCs) are a group of organic compounds that have a molecular structure containing carbon and their chemical properties allow them to be easily converted to steam and gas and remain for a long period of time and have diverse effects on the environment. The purpose of this study is determination of the concentration of VOCs such as alachlor, anthracene, benzene, bromoform, chloroform, heptachlor, isophorone, tetrachloroethylene, γ -chlordane, toluene, etc. in water matrices.

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Background: Hyperglycemia is commonly seen in critically ill patients. This disorder was also seen in coronavirus disease 2019 (COVID-19) patients and was associated with a worse prognosis. The current study determined the prevalence, risk factors, and prognostic implications of hyperglycemia in COVID-19 patients.

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