Publications by authors named "Van Praet Charles"
A comprehensive view of N-glycosylation as clinical biomarker in prostate cancer.
Biochim Biophys Acta Rev Cancer
December 2024
Alterations in the prostate cancer (PCa) N-glycome have gained attention as a potential biomarker. This comprehensive review explores the diversity of N-glycosylation patterns observed in PCa-related cell lines, tissue, serum and urine, focusing on prostate-specific antigen (PSA) and the total pool of glycoproteins. Within the context of PCa, altered N-glycosylation patterns are a mechanism of immune escape and a disruption in normal glycoprotein distribution and trafficking.
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- The study aimed to assess the outcomes of robot-assisted radical cystectomy (RARC) with intracorporeal orthotopic neobladder in women with bladder cancer, specifically focusing on functionality, cancer results, and complications.
- The research involved 146 female patients, revealing that about half underwent pelvic organ-preserving procedures, achieving overall daytime and nighttime continence rates of 54% and 53%.
- The findings concluded that RARC with orthotopic neobladder offers good functional outcomes, with pelvic organ preservation improving urinary continence while maintaining cancer safety.
Background: Muscle invasive bladder cancer (MIBC) treatment combines systemic therapy and radical cystectomy (RC) or local (chemo-)radiotherapy. Response to systemic therapy is an important outcome predictor but is difficult to assess pre-operatively.
Methods: We analyzed multiparametric MRI (mpMRI) in consecutive MIBC patients receiving cisplatin-based neo-adjuvant chemotherapy at our institution.
Article Synopsis
- *Diagnosing MSK can be challenging, especially when there is a concurrent renal mass, which might complicate the imaging results.
- *The report presents a rare case of Bellini duct carcinoma occurring in a patient with MSK, along with a review of related literature on this complex kidney disorder.
Article Synopsis
- The study investigates the use of a radioactive monoclonal antibody, [Zr]Zr-girentuximab, for non-invasive detection of clear-cell renal cell carcinoma in patients with renal masses.
- Conducted across 36 sites in nine countries, the phase 3 trial involved 332 enrolled patients with suspicious renal masses, who received the antibody followed by PET-CT imaging.
- The primary goals of the trial were to assess the sensitivity and specificity of the imaging technique using histopathological confirmation as the standard, with findings from 300 patients eventually analyzed.
Article Synopsis
- Current follow-up for localized prostate cancer mainly relies on prostate-specific antigen (PSA), with no additional biochemical markers widely used.
- A study assessed the urine glycosylation profile of 77 prostate cancer patients and found that lower levels of biantennary core-fucosylation were connected to shorter event-free survival (EFS).
- Combining this urine glycan biomarker with existing clinical risk classifications could enhance patient monitoring and outcomes after primary therapy for prostate cancer.
Article Synopsis
- * Robotic surgery is particularly adept at addressing these challenges, as it allows for the simultaneous display of multiple data inputs to assist the surgeon, though real-time processing of occlusions demands significant computational power.
- * This study introduces a groundbreaking real-time segmentation system tested in three robotic surgeries that enhances safety and usability by accurately identifying non-organic surgical tools, thereby promoting the integration of AR technology in minimally invasive procedures.
How can we reduce morbidity after robot-assisted radical cystectomy with intracorporeal neobladder? A report on postoperative complications by the European Association of Urology Robotic Urology Section Scientific Working Group.
BJU Int
June 2024
Objective: Develop a pioneer surgical anonymization algorithm for reliable and accurate real-time removal of out-of-body images validated across various robotic platforms.
Background: The use of surgical video data has become a common practice in enhancing research and training. Video sharing requires complete anonymization, which, in the case of endoscopic surgery, entails the removal of all nonsurgical video frames where the endoscope can record the patient or operating room staff.
Article Synopsis
- This study looks at what people with serious bladder cancer want when choosing between two treatment options.
- Researchers talked to 16 people who had either surgery or a different treatment to understand their needs and priorities.
- They found that important factors included wanting to be cured, having a good quality of life, trusting their doctor, and getting personalized information about their options.
Background: Tyrosine kinase inhibitors (TKIs) are associated with kidney function deterioration. A shift is ongoing towards glomerular filtration rate (GFR) equations based on other protein markers, such as cystatin C (CSTC) and β-trace protein (BTP). We evaluated various GFR equations for monitoring of kidney function in actively treated oncology patients.
View Article and Find Full Text PDFBackground: In partial nephrectomy for highly complex tumors with expected long ischemia time, renal hypothermia can be used to minimize ischemic parenchymal damage.
Objective: To describe our case series, surgical technique, and early outcomes for robot-assisted partial nephrectomy (RAPN) using intra-arterial cold perfusion through arteriotomy.
Design Setting And Participants: A retrospective analysis was conducted of ten patients with renal tumors (PADUA score 9-13) undergoing RAPN between March 2020 and March 2023 with intra-arterial cooling because of expected arterial clamping times longer than 25 min.
(1) Background: Surgical phases form the basic building blocks for surgical skill assessment, feedback, and teaching. The phase duration itself and its correlation with clinical parameters at diagnosis have not yet been investigated. Novel commercial platforms provide phase indications but have not been assessed for accuracy yet.
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- The PRECISE score was designed to standardize MRI reporting for men with prostate cancer on active surveillance, aiming to improve the assessment of disease progression.
- A study analyzed the diagnostic accuracy and feasibility of the PRECISE score by reviewing MRI scans and patient data from a tertiary referral center over 14 years.
- Results showed that higher PRECISE scores correlated with a significant decrease in progression-free survival, suggesting that the score can effectively indicate clinically important changes in disease status.
Aim: Histidine-containing dipeptides (HCDs) are pleiotropic homeostatic molecules with potent antioxidative and carbonyl quenching properties linked to various inflammatory, metabolic, and neurological diseases, as well as exercise performance. However, the distribution and metabolism of HCDs across tissues and species are still unclear.
Methods: Using a sensitive UHPLC-MS/MS approach and an optimized quantification method, we performed a systematic and extensive profiling of HCDs in the mouse, rat, and human body (in n = 26, n = 25, and n = 19 tissues, respectively).
Purpose: Pronounced underuse of radiotherapy (RT) in muscle-invasive bladder cancer (MIBC) is reported. This study aims to assess the awareness about the role of RT in different MIBC settings and see whether this has increased since 2017.
Materials And Methods: We reviewed the bladder cancer guidelines of the EAU, ESMO, NCCN, NICE, and AUA/ASCO/ASTRO/SUO, focusing on the role of RT in MIBC.
Robot-assisted simple prostatectomy (RASP) and holmium laser enucleation of the prostate (HoLEP) are both well-established, minimally invasive surgical treatment options for lower urinary tract symptoms caused by benign prostatic enlargement. We have reported the first comparative analysis of both techniques in patients with prostates of ≥200 cc. Between 2009 and 2020 a total of 53 patients with a prostate volume of ≥200 cc were surgically treated at OLV Hospital Aalst (Belgium): 31 underwent RASP and 22 underwent HoLEP.
View Article and Find Full Text PDFIntroduction: Surgical removal of the tumor is a key step in the management of nephroblastoma. Less invasive surgical approaches such as robot-assisted radical nephrectomy (RARN) has gained momentum over the past few years. This video presents a comprehensive step-by-step video for two cases: one uncomplicated left RARN and one more challenging right RARN.
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- Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) shows improved early urinary continence compared to standard anterior RARP (SA-RARP) without significant differences in postoperative complications.
- A study involving 100 RS-RARP patients demonstrated that a higher percentage reported being continent at all follow-up intervals, but there was a higher rate of positive surgical margins (PSMs) in RS-RARP patients, particularly in more advanced tumors.
- Overall, the transition to RS-RARP is deemed safe for experienced surgeons, providing better continence outcomes while maintaining comparable biochemical recurrence-free survival rates.
Article Synopsis
- Several barriers hinder the use of augmented reality (AR) in robotic renal surgery, such as visibility issues with instruments and alignment problems of 3D models.
- A deep learning algorithm was developed to detect surgical instruments in real-time during procedures like partial nephrectomy and kidney transplantation, using data from over 65,000 labeled instruments.
- The setup, tested across three hospitals and by four surgeons, improves AR surgery safety but requires further optimization for faster video processing and better handling of organ deformation in clinical settings.
Article Synopsis
- Selective clamping during robot-assisted partial nephrectomy (RAPN) relies on detailed knowledge of a patient's kidney blood flow, which is obtained through imaging technology.
- The study aimed to validate a custom algorithm that generates 3D models of kidney blood supply to enhance surgical planning for 25 patients treated at Ghent University Hospital between 2020 and 2022.
- Results showed the algorithm was highly accurate in predicting the ischemic zones, with high ratings from urologists on its performance, though future studies are needed to fully assess its clinical benefits.
Introduction: To describe the changes in systemic treatments (ST) of synchronous metastatic hormone-sensitive prostate cancer (mHSPC) patients in a "real-world" setting and to explore reasons why contemporary standard of care (SOC) was not administrated to the patient.
Patients And Methods: Since 2014, we prospectively register mHSPCpatients. Patients were grouped in 4 time periods: group 1 (Time period 1, January 2014-July 2015), group 2 after introduction of docetaxel (Time period 2, August 2015-July 2017), group 3 after introduction of abiraterone acetate (Time period 3, August 2017-February 2018) and group 4 after introduction of apalutamide (Time period 4, March 2018-October 2021).
Background: The optimal treatment for patients with pathological node-positive (pN1) prostate cancer (PCa) is unclear.
Objective: To evaluate whether whole-pelvis radiotherapy (WPRT) improves clinical relapse-free survival (cRFS) in comparison to prostate-only radiotherapy (PORT) in pN1 PCa.
Design, Setting, And Participants: PROPER was a phase 3 trial randomizing patients to WPRT or PORT.
Objective: A late conversation about palliative care needs can lead to suboptimal care in the final months/weeks of life. Insight into factors related to patients' communication about palliative care is needed. This study aims to identify the factors associated with starting/intending to start a conversation about palliative care with the physician.
View Article and Find Full Text PDFPeritoneal tuberculosis caused by intravesical instillation with Bacillus Calmette-Guérin (BCG) following nephroureterectomy in a patient with bladder and upper tract urothelial cancer: a case report.
Acta Clin Belg
June 2023
Background: The standard treatment for high-risk non-muscle-invasive bladder cancer (NMIBC) is trans-urethral resection of the bladder (TURB) followed by instillation of Bacillus Calmette-Guérin (BCG). The occurrence of peritoneal tuberculosis after intravesical BCG instillation is extremely rare and difficult to diagnose.
Methods: We report the case of a 79-year-old man with urothelial cell carcinoma (UCC) of the kidney and bladder who developed peritoneal tuberculosis after consecutive TURB and nephroureterectomy followed by intravesical BCG instillation.