Two new flavonoids with antimicrobial activity from the roots of Colebr. ex Wall (Malvaceae).

Two new flavonoids, 4',5,7-trihydroxy-5'-methoxy-6,8-dimethylisoflavone () and 2',5',7-trihydroxy-5-methoxy-6,8-dimethylflavanone () together with the known flavonoids 4´,5,7-trihydroxy-3´-methoxy-6.8-dimethylflavone (), epigallocatechin (), 4´-O-methylepicatechin () and quercetin () were isolated from the roots of . The structures of these compounds were determined by means of spectroscopic methods.

Cytotoxic lignans from fruits of Cleistanthus tonkinensis.

Seven new lignans, cleistonkinins A- E (1-5), cleistonkisides A and B (6-7) were isolated from the fruits of Cleistanthus tonkinensis (Euphorbiaceae), together with five known aryltetralin lignans, cleisindoside B (8), cleistantoxin (9), cleisindoside D (10), neocleistantoxin (11) and polygamain (12). Their structures were established from spectral analysis, including mass spectrometry and 2D-NMR. The absolute configurations of 4-7 were determined by analysis of their experimental CD spectra and comparison with calculated electronic circular dichroism (ECD) spectra.

Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of .

A new flavonoid, macatanarin D (), together with five known stilbenes (), was isolated from fruit glandular trichomes of . Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines.

Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived sp. G248 in East Vietnam Sea.

Three new lavandulylated flavonoids, (2,2'')-6-lavandulyl-7,4'-dimethoxy-5,2'-dihydroxylflavanone (), (2,2'')-6-lavandulyl-5,7,2',4'-tetrahydroxylflavanone (), and (2'')-5'-lavandulyl-2'-methoxy-2,4,4',6'-tetrahydroxylchalcone (), along with seven known compounds were isolated from culture broth of s sp. G248. Their structures were established by spectroscopic data analysis, including 1D and 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS).

Antimicrobial metabolites from a marine-derived Actinomycete sp. G278.

Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete sp. G278 led to the isolation of ten compounds, -. Two compounds, 2,5-Bis(5--butyl-2-benzoxazolyl)thiophene (), and 3-hydroxyl-2-methylpyridine () were isolated from a natural source for the first time.

Synthesis and biological evaluation of febrifugine analogues.

A series of febrifugine analogues were designed and synthesized. Antimalarial activity evaluation of the synthetic compounds indicated that these derivatives had a strong inhibition against both chloroquine-sensitive and -resistant Plasmodium falciparum parasites. Many of them were found to be more active than febrifugine hydrochloride.

Synthesis and biological evaluation of oseltamivir analogues from shikimic acid.

New oseltamivir analogues were designed and synthesized, starting from shikimic acid. Biological evaluation against three human cancer cell lines (KB, MCF7 and Lu-1) showed that many of them exhibited cytotoxic activity. Azides 5 are more active than the corresponding amines 6.