A rare case report of omental synovial sarcoma complicated hemoperitoneum and literature review.

Background: Synovial sarcoma is a rare malignant soft tissue tumor originating mainly in the extremities and usually related to the joint capsule, tendon sheath, or synovial capsule. Only a few cases of synovial sarcoma arising in the abdomen, particularly the omentum, have been reported. We presented a case of omental synovial sarcoma and reviewed 7 cases of this disease.

Discovery of N-(1,4-Benzoxazin-3-one) urea analogs as Mode-Selective TRPV1 antagonists.

A series of 1,4-benzoxazin-3-one analogs were investigated to discover mode-selective TRPV1 antagonists, since such antagonists are predicted to minimize target-based adverse effects. Using the high-affinity antagonist 2 as the lead structure, the structure activity relationship was studied by modifying the A-region through incorporation of a polar side chain on the benzoxazine and then by changing the C-region with a variety of substituted pyridine, pyrazole and thiazole moieties. The t-butyl pyrazole and thiazole C-region analogs provided high potency as well as mode-selectivity.

An efficient framework for lesion segmentation in ultrasound images using global adversarial learning and region-invariant loss.

Lesion segmentation in ultrasound images is an essential yet challenging step for early evaluation and diagnosis of cancers. In recent years, many automatic CNN-based methods have been proposed to assist this task. However, most modern approaches often lack capturing long-range dependencies and prior information making it difficult to identify the lesions with unfixed shapes, sizes, locations, and textures.

Circular economy strategies in the ASEAN region: A comparative study.

Circular Economy (CE) is a sustainable development paradigm that promotes resource efficiency, closed-loop systems, and waste reduction to minimize environmental impacts while fostering economic growth; its popularity is rising at a global scale since the negative effects of linear consumption patterns become more apparent. In this direction, the ASEAN (Association of South East Asian Nations) countries have shown a rising interest in CE due to the region's rapid economic growth and urbanization led to increasing resource consumption and waste generation, which makes CE imperative to safeguard their natural resources and ecosystems. The methodology assessed and compared CE policy documents and academic sources, focusing on excellence and expected impacts, excluding obsolete policies.

An insight of light-enhanced electrochemical kinetic behaviors and interfacial charge transfer of CuInS/MoS-based sensing nanoplatform for ultra-sensitive detection of chloramphenicol.

Owing to the effective combination between MoS sheets with CuInS nanoparticles (NPs), a direct Z-scheme heterojunction was successfully constructed and proved as a promising structure to modify the working electrode surface with the aim of enhancing overall sensing performance towards CAP detection. Herein, MoS was employed as a high mobility carrier transport channel with a strong photo-response, large specific surface area, and high in-plane electron mobility, while CuInS acted as an efficient light absorber. This not only offered a stable nanocomposite structure but also created impressive synergistic effects of high electron conductivity, large surface area, highlight exposure interface, as well as favorable electron transfer process.

Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents.

The toxic pyroglutamate form of amyloid-β (pE-Aβ) is important for the pathogenesis of early Alzheimer's disease (AD); therefore, reducing pE-Aβ by inhibiting glutaminyl cyclase (QC) provides a promising strategy for developing disease-modifying AD drugs. In this study, potent and selective QC inhibitors with desirable drug-like properties were discovered by replacing the 3,4-dimethoxyphenyl group in a QC inhibitor with a bioisosteric indazole surrogate. Among them, 3-methylindazole-6-yl and 3-methylindazole-5-yl derivatives with an N-cyclohexylurea were identified as highly potent inhibitors with IC values of 3.

2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint.

Glutaminyl cyclases (QC, isoQC) convert N-terminal glutamine or glutamate into pyroglutamate (pGlu) on substrates. IsoQC has recently been demonstrated to promote pGlu formation on the N-terminus of CD47, the SIRPα binding site, contributing to the "don't eat me" cancer immune signaling of CD47-SIRPα. We developed new QC inhibitors by applying a structure-based optimization approach starting from fragments identified through library screening.

Multi-Attribute Attention Network for Interpretable Diagnosis of Thyroid Nodules in Ultrasound Images.

Ultrasound (US) is the primary imaging technique for the diagnosis of thyroid cancer. However, accurate identification of nodule malignancy is a challenging task that can elude less-experienced clinicians. Recently, many computer-aided diagnosis (CAD) systems have been proposed to assist this process.

Long Hemodialysis Duration Predicts Delayed Graft Function in Renal Transplant Recipients From Living Donor: A Single-Center Study.

Background: This study aims to determine the ratio of delayed graft function in renal transplant recipients from living donors and the predictive value of hemodialysis time before transplant for delayed graft function.

Methods: We conducted a study on 116 adult patients who were diagnosed with end-stage kidney disease and were treated with hemodialysis and transplanted kidneys from living donors for 2 years (from June 2018 to June 2020). Delayed graft function event was collected for each patient.

An innovative method based on Shannon energy envelope and summit navigation for detecting R peaks of noise stress test signals.

In recent decades, there has been an increased demand for the processing of electrocardiogram (ECG) signals because of its significant role in diagnosing cardiac diseases. The QRS complex is the dominant feature of the ECG signal. The detection of QRS complexes is thus an essential part of almost any ECG signal processing systems.

Serum dioxin concentrations in military workers at three dioxin-contaminated airbases in Vietnam.

An estimated 91,998,400 L of herbicides were stocked at three US airbases in Vietnam between 1962 and 1971. These herbicides were contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-tetraCDD). In 2017, we sampled blood from 120 male Vietnamese military workers in the three dioxin-contaminated airbases (Bien Hoa, Da Nang, and Phu Cat) and from 20 workers at an uncontaminated airbase.

CR-Unet: A Composite Network for Ovary and Follicle Segmentation in Ultrasound Images.

Transvaginal ultrasound (TVUS) is widely used in infertility treatment. The size and shape of the ovary and follicles must be measured manually for assessing their physiological status by sonographers. However, this process is extremely time-consuming and operator-dependent.

Successful intralipid-emulsion treatment of local anesthetic systemic toxicity following ultrasound-guided brachial plexus block: case report.

Background: Local anesthetic systemic toxicity (LAST) is a life-threatening complication that may follow application of LAs through various routes. Despite increasing usage of LA techniques in a large number of health-care settings, contemporary awareness of LAST and understanding of its management are inadequate.

Case Presentation: We report two cases who suffered LAST following brachial plexus block for surgery on the upper extremity.

Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors.

Glutamyl cyclase (QC) is a promising therapeutic target because of its involvement in the pathogenesis of Alzheimer's disease. In this study, we developed novel QC inhibitors that contain 3-aminoalkyloxy-4-methoxyphenyl and 4-aminoalkyloxyphenyl groups to replace the previously developed pharmacophore. Several potent inhibitors were identified, showing IC values in a low nanomolar range, and were further studied for in vitro toxicity and in vivo activity.

Reducing Liver Cancer Risk in African-Born Immigrants Through Culturally Targeted Hepatitis B Group Education Programs.

Of 900 West African-born immigrants living in New York City who were tested for hepatitis B virus (HBV), over 9% were found to have the infection (Shankar H et al. Clin Infectious Dis 62(S4):S289-s297, 2016). Community targeted group education programs (EP) have been shown to improve immigrant population's health (Bailey E et al.

Synergistic intrafibrillar/extrafibrillar mineralization of collagen scaffolds based on a biomimetic strategy to promote the regeneration of bone defects.

The mineralization of collagen scaffolds can improve their mechanical properties and biocompatibility, thereby providing an appropriate microenvironment for bone regeneration. The primary purpose of the present study is to fabricate a synergistically intra- and extrafibrillar mineralized collagen scaffold, which has many advantages in terms of biocompatibility, biomechanical properties, and further osteogenic potential. In this study, mineralized collagen scaffolds were fabricated using a traditional mineralization method (ie, immersed in simulated body fluid) as a control group and using a biomimetic method based on the polymer-induced liquid precursor process as an experimental group.