Publications by authors named "Van Dinh Trang"
Interpreting the phenotypes of alleles in genomes is complex. Whilst all strains are expected to carry a chromosomal copy conferring resistance to ampicillin, they may also carry mutations in chromosomal alleles or additional plasmid-borne alleles that have extended-spectrum β-lactamase (ESBL) activity and/or β-lactamase inhibitor (BLI) resistance activity. In addition, the role of individual mutations/a changes is not completely documented or understood.
View Article and Find Full Text PDFArticle Synopsis
- * A study in Vietnam involving 330 patients compared the BioFire FilmArray Meningitis/Encephalitis (FAME) Panel to traditional diagnostic methods, with FAME showing an 87% agreement rate and detecting 19% of specimens.
- * While FAME offers rapid pathogen detection, it's not a complete replacement for traditional methods and should be tailored to local disease patterns to improve healthcare outcomes.
Article Synopsis
- * The simultaneous presence of Delta and Omicron variants raised concerns about co-infection and potential genetic recombination, as revealed through genomic sequencing of viral RNA samples from positive cases.
- * A study identified a case of co-infection with Delta AY.57 and Omicron BA.1, as well as two recombinant cases with traits from Delta AY.57 and Omicron BA.2, underscoring the importance of genomic surveillance for tracking viral mutations and changes in transmissibility or severity.
Case-based surveillance of antimicrobial resistance (AMR) provides more actionable data than isolate- or sample-based surveillance. We developed A Clinically Oriented antimicrobial Resistance surveillance Network (ACORN) as a lightweight but comprehensive platform, in which we combine clinical data collection with diagnostic stewardship, microbiological data collection and visualisation of the linked clinical-microbiology dataset. Data are compatible with WHO GLASS surveillance and can be stratified by syndrome and other metadata.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied 1,303 SARS-CoV-2 whole-genome sequences from Vietnam to identify the major variants responsible for the COVID-19 outbreak in 2021.
- The Alpha and Delta variants, specifically the AY.57 lineage of Delta, were linked to over 1.7 million infections and more than 32,000 deaths.
- Nonpharmaceutical interventions significantly influenced the spread of the virus during this outbreak.
Coronavirus disease 2019 (COVID-19) and associated social responses may uniquely affect people living with HIV (PLHIV). SARS-CoV-2 antibody testing and a cross-sectional survey on COVID-19's socio-behavioral impacts were conducted among a large PLHIV cohort in Hanoi, Vietnam. We examined anonymous antibody test results for 1243 PLHIV (99.
View Article and Find Full Text PDFWe performed a retrospective case-series study of patients with influenza A (H5N1) admitted to the National Institute of Infectious and Tropical Diseases in Hanoi, Vietnam, from January 2004 through July 2005 with symptoms of acute respiratory tract infection, a history of high-risk exposure or chest radiographic findings such as pneumonia, and positive findings for A/H5 viral RNA by reverse transcription-PCR. We investigated data from 29 patients (mean age 35.1 years) of whom 7 (24.
View Article and Find Full Text PDF