Publications by authors named "Vamika Karn"
Article Synopsis
- * Current treatments like chemotherapy and radiotherapy have limited success, highlighting the need for new approaches to therapy.
- * Research suggests that extracellular vesicles (EVs) are important for communication between cancer cells and their environment, influencing cancer behaviors such as growth, spread, and resistance to treatments, with potential use as biomarkers and drug delivery systems.
Mechanistic influence of discreet conformation of human telomerase linker region.
J Biomol Struct Dyn
February 2024
Approximately 90% of malignancies have been shown to have human telomerase activity, establishing it as a viable therapeutic target. The crystal structure of telomerase was determined recently. However, the tertiary structure of the non-conserved flexible linker region remains unresolved.
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- - Cancer is a significant global health concern, with breast cancer being the most common type affecting women, leading to the need for effective treatment strategies like surgery, radiation, and chemotherapy.
- - Ongoing research aims to develop new therapies with lower toxicity, including gene therapy, which seeks to correct defective genes involved in cancer.
- - CRISPR/Cas9 has emerged as a powerful gene-editing tool that enhances targeted therapies by addressing drug resistance and improving immunotherapy for breast cancer, due to its precision and cost-effectiveness.
The COVID-19 pandemic has become a serious concern and has negatively impacted public health and the economy. It primarily targets the lungs, causing acute respiratory distress syndrome (ARDS); however, it may also lead to multiple organ failure (MOF) and enhanced mortality rates. Hence, there is an urgent need to develop potential effective therapeutic strategies for COVID-19 patients.
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