Publications by authors named "Valter Augusto Della-Rosa"
Terbinafine is an antimycotic drug usually used against several superficial fungal infections and with a potential application in the treatment of human cancers. Since to date there are few data on the genotoxic effects of terbinafine in mammalian cells, current study evaluated the potential genotoxic of such antifungal agent in cultured human peripheral blood lymphocytes. Terbinafine was used at the peak plasma concentration (1.
View Article and Find Full Text PDFPurpose: To evaluate the cochlear function of parents of individuals with autosomal recessive gene Gap Junction Protein Beta-2 hearing loss by ultra-high frequencies distortion-product otoacoustic emissions (DPOAEs), compared with responses of a control group matched for age and gender.
Methods: We studied 56 subjects aged from 20 to 58 years, divided into two groups. The study group comprised 28 parents of hearing-impaired patients due to autosomal recessive inheritance, 14 females aged 20.
Article Synopsis
- The study investigates the frequency of the A1555G mutation in the MT-RNR1 gene among Brazilians with nonsyndromic deafness and compares it to normal-hearing individuals.
- Out of 78 analyzed deaf individuals, only 1.3% had the A1555G mutation, while no mutations were found in the 70 non-impaired individuals.
- The findings suggest that the A1555G mutation is rare among normal-hearing individuals in Paraná, Brazil, but its presence in deaf individuals aligns with frequencies observed in other populations, highlighting its importance in genetic counseling for deafness.
Three new cases of DOOR syndrome are described in unrelated Brazilian children. One of these cases also has a congential cardiac defect. None of the cases has organic acid abnormalities and they can therefore be classified as Type II.
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