Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats.

In this work, the potential usefulness of silver nanoparticles (AgNPs) for treating burn wounds was examined. Second-degree burns were induced in male Wistar rats by touching the skin with a heated (70°C) metallic device for 10 s, after which the animals were randomly allocated to one of two groups: control (n=8, treated with sterile saline) and experimental (n=8, treated with AgNPs, 0.081 mg/mL; 50 µL applied to the burn surface).

Experimental model for removal of snake venom via hemoperfusion in rats.

Objective: To examine the efficiency of hemoperfusion in removing South American rattlesnake (Crotalus durissus terrificus) venom from rats compared with neutralization by antivenom.

Design: An exploratory experimental investigation in rats involving the injection of snake venom with or without subsequent hemoperfusion or antivenom administration.

Setting: Basic animal research laboratory in a private university.

Acute kidney injury caused by the intraperitoneal injection of venom in rats.

We examined the ability of venom (12.5 mg/kg) injected intraperitoneally (i.p.

Prospective study of a venom batch (Bj2015) - phospholipase A activity, immunogenicity, neurotoxicity, and myotoxicity parameters.

venom's (Bj2015) batch was biomonitored quarterly for one year to assess phospholipase A (PLA) activity, immunogenicity, neurotoxicity, and myotoxicity. models were applied to evaluate losses using decay model and recoveries by predictive trend analysis. Mice were immunized with Bj2015.

Clinical comparison of salicylic acid peel and LED-Laser phototherapy for the treatment of Acne vulgaris in teenagers.

Acne vulgaris treatments usually cause sensitivity, teratogenicity and bacterial resistance. Investigations of other therapeutic techniques, such as phototherapy, are highly relevant. Thus, we compared the effectiveness of two Acne vulgaris treatments in adolescents: peeling with salicylic acid (SA) and phototherapy.

Development and evaluation of a floating multiparticulate gastroretentive system for modified release of AZT.

The aim of this study was to develop and evaluate a floating multiparticulate gastroretentive system for the modified release of zidovudine (AZT). AZT was used as a model drug water-soluble at therapeutic doses. The floating gastroretentive system was obtained by co-precipitation, after solvent diffusion and evaporation.