Publications by authors named "Vallone V"
Introduction: Like other forms of neuropathology, gliomas appear to spread along neural pathways. Accordingly, our group and others have previously shown that brain network connectivity is highly predictive of glioma survival. In this study, we aimed to examine the molecular mechanisms of this relationship via imaging transcriptomics.
View Article and Find Full Text PDFLike other forms of neuropathology, gliomas appear to spread along neural pathways. Accordingly, our group and others have previously shown that brain network connectivity is highly predictive of glioma survival. In this study, we aimed to examine the molecular mechanisms of this relationship via imaging transcriptomics.
View Article and Find Full Text PDFAim: To investigate the effects of anticancer therapy on dental development and caries formation in Italian childhood cancer survivors compared to healthy controls.
Methods: A total of 52 children treated with chemotherapy and/or radiotherapy when younger than 10 years and in remission from at least 2 years, and 52 healthy age- and gender-matched children were consecutively enrolled in this cross-sectional study. All participants were examined for dental caries and enamel defects according to the decayed-missing-filled teeth (dmft/DMFT) index and the Aine rating scale.
Aim: To compare accuracy, efficacy and acceptance of implantable and transcutaneous continuous glucose monitoring (CGM) systems.
Methods: In a randomized crossover trial we compared 12 weeks with Eversense implantable sensor (EVS) and 12 weeks with Dexcom G5 transcutaneous sensor (DG5) in terms of accuracy, evaluated as Mean Absolute Relative Difference (MARD) vs capillary glucose (SMBG), time of CGM use, adverse events, efficacy (as HbA1c, time in range, time above and below range) and psychological outcomes evaluated with Diabetes Treatment Satisfaction Questionnaire (DTSQ), Glucose Monitoring Satisfaction Survey (GMSS), Hypoglycemia Fear Survey (HFS2), Diabetes Distress Scale (DDS).
Results: 16 subjects (13 males, 48.
Comparing the accuracy of transcutaneous sensor and 90-day implantable glucose sensor.
Nutr Metab Cardiovasc Dis
February 2021
Article Synopsis
- Continuous glucose monitoring (CGM) is essential for managing diabetes, and this study assessed the accuracy of two sensors: Dexcom G5 Mobile (DG5) and Eversense (EVS).
- Eleven patients with type 1 diabetes wore both sensors for seven days, undergoing controlled glucose excursions in a clinical research center.
- The results showed that DG5 had better accuracy in a clinical setting, especially during blood glucose decreases, whereas both sensors performed similarly during home monitoring.
Article Synopsis
- Pregnant women with type 1 diabetes (T1D) using continuous insulin infusion have higher complication risks, but pregnancy planning might help improve outcomes.
- A study of 107 pregnancies showed that those who planned their pregnancies had better glucose control and lower risks of preterm delivery compared to unplanned pregnancies.
- Better glucose control and reduced preterm delivery risks were linked to pregnancy planning, emphasizing the importance of preconception care for T1D patients using advanced insulin delivery methods.
Methods for Automated Single Cell Isolation and Sub-Cloning of Human Pluripotent Stem Cells.
Curr Protoc Stem Cell Biol
December 2020
Article Synopsis
- * The text discusses three automated devices that streamline the single-cell cloning process for hPSCs, presenting them as more efficient and reliable alternatives to labor-intensive manual methods.
- * The proposed workflows successfully maintain the pluripotency and genetic stability of sub-clones and can also help identify genetic diversity (karyotypic mosaicism) in hPSC cultures, enhancing high-throughput clonal selection needed for advancing stem cell applications.
Article Synopsis
- - The Steno T1D Risk Engine aims to assess cardiovascular risk in individuals with type 1 diabetes (T1D) and was originally validated in northern European populations, prompting an evaluation of its effectiveness in Italian T1D patients.
- - In a study involving 223 Italian patients, the engine predicted a 5-year cardiovascular risk of 5.9%, which was associated with the presence of subclinical atherosclerosis but not inflammation markers; only three actual cardiovascular events were recorded over a mean follow-up of 4.7 years.
- - The findings indicate that while the Steno T1D Risk Score can identify individuals at high risk for cardiovascular issues, it tends to overestimate the actual occurrence of events,
Background And Aims: This study compared the accuracy of the FreeStyle Libre (Abbott, Alameda, CA) and Dexcom G4 Platinum (DG4P, Dexcom, San Diego, CA) CGM sensors.
Methods And Results: Twenty-two adults with type 1 diabetes wore the two sensors simultaneously for 2 weeks. Libre was used according to manufacturer-specified lifetime (MSL); DG4P was used 7 days beyond MSL.
Article Synopsis
- Researchers developed a new method to isolate and study fetal progenitor cells from the digestive tract, focusing on their characteristics before they fully differentiate.
- In 2013, Mustata successfully isolated fetal intestinal progenitors that grew as spheroids, using a culture system originally meant for adult stem cells.
- The study presents a refined protocol for isolating and maintaining gastric spheroids from the distal pre-glandular stomach, highlighting their strong self-renewal abilities.
Article Synopsis
- The tri-dimensional culture technique, first described by Sato in 2009, helps isolate and grow epithelial stem cells from various organs, starting with the adult small intestine.
- Barker built on this method in 2010 by isolating antral stem cells to create organoids that mimic the mature pyloric epithelium, aiding in the study of gastric health and disease.
- The authors adapted Barker's protocol to examine both stable and regenerating tissues, providing detailed steps for isolating and culturing antral glands and individual cells for potential further research.
Article Synopsis
- The study aimed to examine the experiences of children with type 1 diabetes and their parents during a 7-day summer camp focused on an artificial pancreas clinical trial.
- Interviews revealed that while parents were mainly curious about the device's safety and effectiveness, children were excited about trying out the new technology.
- Results showed that most parents found the artificial pancreas easy to use and believed it could improve glucose control, indicating a generally positive reception and the need for further research to better tailor the device to participants' needs.
Article Synopsis
- The PedArPan project tested a children's version of the modular model predictive control (MMPC) algorithm in children aged 5 to 9 with type 1 diabetes during a camp outing.
- In a randomized trial with 30 participants, the artificial pancreas (AP) was compared to parent-managed sensor-augmented pump (SAP) over six days.
- Results indicated that the AP significantly reduced overnight hypoglycemia but also led to higher average glucose levels and slightly decreased time within the target glucose range, suggesting that algorithm improvements are needed for better efficacy.
Article Synopsis
- The study aimed to understand how the autonomic nervous system affects the sprint performance of young soccer players, particularly focusing on their neuromuscular power.
- Twelve young players, averaging 15 years old, underwent heart rate variability assessments and completed multiple cycling sprints to measure their peak and mean power output.
- Results indicated that a higher baseline parasympathetic activity was linked to better performance in sprints, suggesting that monitoring heart rate variability could help gauge athletes' readiness for high-intensity exercise.
Bone metastasis is an incurable complication of breast cancer affecting 70-80 % of advanced patients. It is a multistep process that includes tumour cell mobilisation, intravasation, survival in the circulation, extravasation, migration and proliferation in the bone marrow/bone. Although novel findings demonstrate the bone marrow microenvironment significance in bone metastatic progression, a majority of studies have focused on end-stage disease and little is known about how the pre-metastatic niche arises in the bone marrow/bone tissues.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how periprostatic adipose tissue (PPAT) from patients with benign prostatic hyperplasia (BPH) compares to that of prostate cancer (PCa) patients in influencing cancer cell behavior.
- - Researchers analyzed how conditioned media from BPH and PCa PPAT affected adhesion, growth, migration, and enzyme expression in androgen-dependent (LNCaP) and androgen-independent (PC3) prostate cancer cells.
- - The findings suggest that factors from PPAT, especially pro-MMP-9, could enhance the invasive traits of LNCaP cells, indicating that PPAT may play a role in the early progression of prostate cancer.
Article Synopsis
- - Breast cancer (BC) is a leading cause of death for women globally, with many patients developing metastases, particularly to bones, in 65-80% of cases, highlighting a need to understand the underlying mechanisms of dormancy and spread.
- - The study examined the expression and release of various proteins (OPG, RANKL, TRAIL, SDF-1) and their receptors in two human BC cell lines, MDA-MB-231 and MCF-7, using various analytical methods, finding that MCF-7 cells released more OPG.
- - Results showed that both cell lines expressed important molecules related to tumor progression and bone metastasis, suggesting that analyzing these proteins in breast cancer patients
Mesenchymal stromal cells, colony-forming unit fibroblasts, from bone marrow of untreated advanced breast and lung cancer patients suppress fibroblast colony formation from healthy marrow.
Stem Cells Dev
March 2010
Article Synopsis
- Advanced lung and breast cancer patients have reduced numbers of bone marrow colony-forming unit fibroblasts (CFU-Fs), affecting stem cell proliferation and differentiation due to their unique bone marrow microenvironment.
- Conditioned media from these cancer patients' CFU-F-derived stromal cells also decrease the colony-forming efficiency of healthy individuals' CFU-Fs, leading to larger stromal cells that deviate from the normal morphology.
- Increased levels of GM-CSF, along with low bFGF and Dkk-1 concentrations in patients' conditioned media, contribute to the impaired function and maturation of mesenchymal stem cells (MSCs), which remain largely unresponsive in standard growth conditions.
The purpose of this paper is to extend the research on the Duss Fairy Tales in an Italian sample. Attention has been paid, in particular, to the study of some variables identified in a newly devised schedule. The protocols were scored for four indexes: (1) the main hero of the stories, (2) number and types of characters, (3) number of emotions expressed, and (4) number of heroes' and characters' actions and behaviors.
View Article and Find Full Text PDF