Seven cases of hereditary haemorrhagic telangiectasia-like hepatic vascular abnormalities associated with pathogenic variants.

Background: loss of function is associated with type 2 capillary malformation-arteriovenous malformation syndrome, an autosomal dominant vascular disorder. The phenotype partially overlaps with hereditary haemorrhagic telangiectasia (HHT) due to epistaxis, telangiectases and cerebral arteriovenous malformations, but a similar liver involvement has never been described.

Methods: Members of the French HHT network reported their cases of mutation identified after an initial suspicion of HHT.

Prophylactic sequential antibiotic therapy for recurrent liver/biliary sepsis.

Background And Aims: Recurrent liver/biliary sepsis are rare and can occur in different situations. Curative treatment of acute septic episodes is based on antibiotics. Nevertheless, recurrent sepsis can be life-threatening, and the treatment of the underlying disease could be complex, and eventually not possible.

Digestive perforations related to endoscopy procedures: a local management charter based on local evidence and experts' opinion.

Perforations are a known adverse event of endoscopy procedures; a proposal for appropriate management should be available in each center as recommended by the European Society of Gastrointestinal Endoscopy. The objective of this study was to establish a charter for the management of endoscopic perforations, based on local evidence. Patients were included if they experienced partial or complete perforation during an endoscopic procedure between 2008 and 2018 (retrospectively until 2016, then prospectively).

Polycystic liver: automatic segmentation using deep learning on CT is faster and as accurate compared to manual segmentation.

Objective: This study aimed to develop and investigate the performance of a deep learning model based on a convolutional neural network (CNN) for the automatic segmentation of polycystic livers at CT imaging.

Method: This retrospective study used CT images of polycystic livers. To develop the CNN, supervised training and validation phases were performed using 190 CT series.

A 600 years sediment record of heavy metal pollution history in the Danube Delta.

Heavy metal pollution in the Danube Delta (in sediments, water and living organisms) has recently received increasing attention due to its impact on ecosystems health and water quality. However, long term records of heavy metal contamination are not available to date. In this study radiometric dating and geochemical analyses for major elements (Al, Fe, Ca and S) and metals (Cu, Zn, Pb, Ni, Cr and Cd) were performed on the top 4 m of a 9-m sediment core retrieved from the alluvial plain of Sulina distributary channel aiming to reconstruct the heavy metal geological background and contamination history and discuss the possible origins (natural vs.

Intestinal Conventional Ultrasonography, Contrast-Enhanced Ultrasonography and Magnetic Resonance Enterography in Assessment of Crohn's Disease Activity: A Comparison with Surgical Histopathology Analysis.

Background And Aims: Contrast-enhanced ultrasonography (CEUS) is a potential interesting method for assessing accurately Crohn's disease (CD) activity. We compared the value of intestinal ultrasonography (US) coupled with contrast agent injection with that of magnetic resonance enterography (MRE) in the assessment of small bowel CD activity using surgical histopathology analysis as reference.

Methods: Seventeen clinically active CD patients (14 women, mean age 33 years) requiring an ileal or ileocolonic resection were prospectively enrolled.

Diffuse Versus Localized Caroli Disease: A Comparative MRCP Study.

The purpose of this multicenter retrospective study was to assess the MRCP features of Caroli disease (CD). Sixty-six patients were identified from 2000 to 2019. The inclusion criteria were diagnosis of diffuse or localized CD mentioned in an imaging report, presence of intrahepatic bile duct (IHBD) dilatation, and having undergone an MRCP examination.

Partial major hepatectomy with cyst fenestration for polycystic liver disease: Indications, short and long-term outcomes.

Background And Objective: Symptomatic polycystic liver disease (PLD) with massive hepatomegaly represents a challenging surgical issue. In this work, we focused on early and long term outcomes after partial hepatectomy with cyst fenestration (PHCF) in selected patients.

Methods: All patients who had PHCF for treatment of PLD between January 2003 and December 2019 in our center were included in this study.

[Can we talk about triage of patients and with whom?].

During the first wave of the Covid-19 epidemic that hit France in the spring of 2020 sparked controversy over the triage of patients in the emergency room. From this controversy, this text will seek to clarify this notion of triage and, and to shed light on the ethical position of bedside physicians who find themselves summited to public health strategies, scientific data, regulatory injunctions and ethical duties.

Management and Prognosis of Localized Duodenal Neuroendocrine Neoplasms.

Introduction: The characteristics, prognostic factors, and management of duodenal neuroendocrine neoplasms (dNEN) are ill-defined, given their rarity. Whether nonsurgical management might be appropriate for patients with nonmetastatic dNEN and a good prognosis, as is the case for pancreatic NEN (pNEN), is unknown. We aimed to describe the management and prognosis of nonmetastatic dNEN patients.

Anastomotic bilio-biliary stricture after adult liver transplantation: A retrospective study over 20 years in a single center.

Background: Biliary complications are the main surgical complication after liver transplantation (LT). The aims of the present retrospective single center study were to describe anastomotic bilio-biliary strictures (ABS) in a large cohort of liver transplant recipients with long follow-up.

Methods: All adult LT recipients who underwent a LT, with bilio-biliary anastomosis, between 1990 and 2010 in Edouard Herriot hospital, Lyon, France were included in the study.

Evaluation of a strategy using pretherapeutic fiducial marker placement to avoid missing liver metastases.

Background: Hepatic surgery is appropriate for selected patients with colorectal liver metastases (CRLM). Advances in chemotherapy have led to modification of management, particularly when metastases disappear. Treatment should address all initial CRLM sites based on pretherapeutic cross-sectional imaging.