Publications by authors named "Valery V Aleksandrin"
Coronary artery disease (CAD) and the coronary artery bypass graft (CABG) are associated with a decreased blood glutathione (bGSH) level. Since GSH metabolism is closely related to other aminothiols (homocysteine and cysteine) and glucose, the aim of this study was to reveal the associations of bGSH with glucose and plasma aminothiols in CAD patients (N = 35) before CABG and in the early postoperative period. Forty-three volunteers with no history of cardiovascular disease formed the control group.
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- A new method using capillary electrophoresis has been developed to accurately measure reduced glutathione (GSH) and oxidized glutathione disulfide (GSSG) in whole blood.
- The process includes stable sample preparations and a fast analysis time of only 8 minutes, with quantification limits for GSSG at 1.5 µM.
- Results from healthy volunteers show average levels of GSH, GSSG, and their ratio, indicating that this approach is suitable for clinical and laboratory applications.
The purpose of the present study was to investigate the use of laser Doppler flowmetry (LDF) signals coupled with spectral wavelet analysis to detect endothelial link dysfunction in the autoregulation of cerebral blood flow in the setting of hyperhomocysteinaemia (HHcy). Fifty-one rats were assigned to three groups (intact, control, and HHcy) according to the results of biochemical assays of homocysteine level in blood plasma. LDF signals on the rat brain were recorded by LAKK-02 device to measure the microcirculatory blood flow.
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