Hypertrophic cardiomyopathy induces changes in the tryptophan-5-hydroxylase, serotonin transporter and serotonergic receptors expressions.

Introduction: Cardiomyocytes have a biochemical machinery with the capacity to synthesize, utilize and reuptake serotonin.

Objective: To determine whether hypertrophic cardiomyopathy (HCM) induces changes in the expression of tryptophan-5-hydroxylase (TPH) 1 and 2, serotonin transporter (SERT) and serotonergic receptors (SR).

Methods: Cross-sectional study of five tissue blocks from hearts with HCM and five controls.

Triptófano-5-hidroxilasa, transportador de serotonina y receptores serotoninérgicos en miocardiopatía dilatada.

Background: Cardiomyocytes synthesize, utilize and reuptake serotonin, which is involved in the paracrine and autocrine modulation of heart activity and in the pathophysiology of some cardiovascular diseases.

Objective: To determine the expression of tryptophan-5-hydroxylase (TPH) 1 and 2, serotonin transporter protein (SERT) and serotonergic receptors in hearts with dilated cardiomyopathy (DCM) compared to controls.

Method: A comparative study was performed in six tissue blocks of the left ventricular free wall (LVWL) and inter-ventricular septum from patients who died of DCM and six who died of no cardiovascular diseases (controls).

[Tumors of the heart. 16 years experience in Hospital de Cardiología, del Centro Médico Nacional Siglo XXI in Mexico City].

Introduction: We present incidence of primary cardiac tumors diagnosed from 1987 at the Hospital de Cardiología, Centro Médico Nacional Siglo XXI, in Mexico City.

Objective: We described primary cardiac tumors based on histopathologic diagnosis, frequency, localization, implantation, implantation site, and recurrence.

Material And Methods: A total of 51 patient files were selected retrospectively.

Wolff-Parkinson-White syndrome associated to scimitar syndrome. Percutaneous radiofrequency catheter ablation previous to surgical repair.

Scimitar syndrome and Wolff-Parkinson-White association has not been reported during the era of catheter ablation. We present our personal experience with percutaneous radiofrequency ablation, a technical challenge related with Scimitar's anatomical variants and follow-up after surgical repair of the latter.

[Design and development of a stent (SAQ) for the treatment of arterial coronary arterioscleotic obstruction].

The practice of percutaneous transluminal coronary angioplasty has shown that the major complications are acute dissection as well as suboptimal results and restenosis. The effort to reduce these complications has led to create an intravascular device called Stent. The technology is complex and very expensive, for this reason we designed and made a new model of stent named SAQ.

[The relationship between Chlamydia pneumoniae and atherosclerotic lesions of the aorta].

Although atherogenic main factors have been extensively studied, there are others whose real importance has not been well defined. There are some pathologic and immunologic evidences relating several infectious agents with the genesis or development of coronary atherosclerosis. Recently, a link has been established between Chlamydia pneumoniae and atherogenesis, due to immunological evidence of infection in human atherosclerotic lesions.

[In vitro effects of argon laser radiation the human healthy and atherosclerotic aorta].

Argon laser exposures in vitro were done on human aortas. The laser energy applied on a fresh aorta section (A) was from 100mw to 1000mw. A second aorta section (B), formalin fixed, was irradiated under saline solution by a fiberoptic system.