Publications by authors named "Valeriya O Babich"
Int J Mol Sci
October 2020
Article Synopsis
- Plant-extracted triterpenoids, like 18βH-glycyrrhetinic acid's derivative SM, are bioactive compounds known for their various health benefits, such as reducing inflammation and oxidative stress.
- In laboratory tests on macrophages (a type of immune cell), SM showed potential by lowering harmful substances and boosting protective compounds, although it also increased certain pro-inflammatory cytokines.
- In animal models, SM effectively reduced inflammation in certain conditions but did not provide relief in cases of endotoxemia, indicating its effects might vary depending on the type of inflammation.
Article Synopsis
- A series of deoxycholic acid derivatives with aliphatic diamines and aminoalcohols or morpholines were synthesized via epoxide ring-opening and tested for cytotoxicity against various human tumor cell lines and macrophages.*
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- The results showed that these new compounds were significantly more cytotoxic than the original deoxycholic acid; aminoalcohols were particularly effective in selectively targeting tumor cells.*
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- The most effective compounds initiated cell death through a mechanism involving reactive oxygen species (ROS), activating apoptosis and autophagy, with a primary target identified as the vitamin D receptor.*
Article Synopsis
- Novel deoxycholic acid derivatives were synthesized with different substituents at the C-3 position, yielding promising new compounds for anti-tumor activity.
- In vitro tests revealed that derivatives with heterocyclic substituents were more effective against tumor cells than those with aryl groups, with varying levels of sensitivity across different cancer cell lines.
- Additionally, these compounds showed anti-inflammatory effects by significantly reducing NO synthesis in macrophages and were effective in animal models of edema.
Bioorg Med Chem Lett
August 2017
Article Synopsis
- * The newly synthesized compounds were tested for their effectiveness in killing cancer cells, with some showing better results than the original DCA.
- * One particular compound with 1-methylpiperazine was highlighted as especially effective, demonstrating strong anti-cancer properties and selectivity against specific liver cancer cell lines.
