Publications by authors named "Valeriya Chugaeva"
The fidelity of the early embryonic program is underlined by tight regulation of the chromatin. Yet, how the chromatin is organized to prohibit the reversal of the developmental program remains unclear. Specifically, the totipotency-to-pluripotency transition marks one of the most dramatic events to the chromatin, and yet, the nature of histone alterations underlying this process is incompletely characterized.
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- The research provides effective methods for culturing post-implantation mouse embryos outside the uterus, from just before gastrulation (E5.5) to hindlimb formation (E11).
- This culture system utilizes both static and rotating environments to mimic natural development processes and has been validated through multiple analyses, showing that these embryos develop similarly to those inside the uterus.
- The ability to manipulate and study these embryos in a controlled environment opens new avenues for understanding embryogenesis and the processes involved in mammalian development.