Autophagy and vesicular trafficking in human uveal melanoma: A histopathological study.

Uveal melanoma is an ocular tumor with a high risk of developing metastases. The endo-lysosomal system can affect the melanoma progression by accelerating and facilitating invasion or metastasis. This study aims to conduct comparative analysis of normal choroidal melanocytes and uveal melanoma cells ultrastructure with a focus on intracellular transport system, and to examine the patterns of autophagy- and vesicular trafficking-related proteins expression in a case series of uveal melanomas.

gene polymorphisms: association with age-related macular degeneration in Russian population.

Aim: To study polymorphisms in promotor regions of (rs1800630), (rs1800629), and (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex genotypes with AMD.

Methods: One hundred and two patients (82 women, 20 men; mean age 64.2±1.

Cystatin C and lactoferrin concentrations in biological fluids as possible prognostic factors in eye tumor development.

Objectives: To investigate the possible role of cystatin C in eye biological fluids locally and in serum and lactoferrin revealing anti-tumor activity in eye tumor development.

Background: The increased number of eye tumors was registered recently not only in the countries with high insolation, but also in the northern countries including Russia (11 cases per million of population). Search for new biological markers is important for diagnosis and prognosis in eye tumors.