Publications by authors named "Valeriy Borukov"
Article Synopsis
- Primary age-related tauopathy (PART) is a neurodegenerative disease distinguished from Alzheimer’s disease (AD) by the absence of amyloid-β plaques, while still exhibiting similar neurofibrillary degeneration and cognitive impairment.
- A genetic study involving 647 individuals with PART identified significant genetic associations with known loci related to AD and other tauopathies, particularly highlighting a new link to the JADE1 gene located on chromosome 4.
- Experimental findings showed that JADE1 is associated with tau aggregates in the brain and its knockdown in a fruit fly model resulted in increased tau-induced toxicity, suggesting that JADE1 may play a crucial role in the progression of PART.
Objective: Abnormal deposition of the antimicrobial peptide amyloid beta (Aβ) is a characteristic of Alzheimer's disease. The objective of this study was to elucidate risk factors for brain Aβ in a cohort enriched for HIV and other neurotropic pathogens.
Design: Cross-sectional cohort study.