Publications by authors named "Valerio Orlandi"
Cocaine snorting may induce ocular surface damage through corneal sensitivity impairment.
Graefes Arch Clin Exp Ophthalmol
May 2015
Purpose: Cocaine abuse may cause severe ischemic and necrotic tissue damage in several organs, including the eye. However, the cornea is an avascular tissue relying on sensitive nerves for its trophic support, and the pathogenesis of cocaine-induced corneal lesions is unclear. In this study, we aimed to investigate if corneal sensitivity, ocular surface, and tear function are damaged by habitual cocaine snorting.
View Article and Find Full Text PDFBackground: Headache is one of the most common symptoms after cocaine use.
Methods: We investigated headache frequency and characteristics and the correlation between headache and acute cocaine intake in a cross-sectional study in a consecutive series of chronic cocaine users.
Results: Participation rate was 94.
Article Synopsis
- Primary polydipsia (PP) is a common and potentially dangerous complication for chronic schizophrenic patients, requiring early diagnosis and treatment to prevent serious consequences like hyponatremia and coma.
- The exact cause of PP is still not well understood, making it challenging to find effective drug treatments; conventional antipsychotics may worsen the condition, while newer atypical antipsychotics yield mixed results.
- A case study analysis highlights the current state of research on treating PP with atypical antipsychotics in schizophrenia, noting that while some medications like clozapine show promise, their management can be complex.
Combining an SSRI with an anticonvulsant in depressed patients with dysphoric mood: an open study.
Clin Pract Epidemiol Ment Health
February 2007
Background: Several patients with unipolar depression present with prominent dysphoric mood. We aimed at examining the effectiveness of the combination of an SSRI with an anticonvulsant in such patients.
Methods: Thirty-five newly admitted outpatients with substantial anger, irritability, aggressiveness or hostility who were diagnosed a DSM-IV unipolar depressive disorder were rated on the Hamilton Depression Rating Scale (HDRS), the Clinical Global Improvement (CGI) scale, and a scale for the rapid dimensional assessment (SVARAD), were prescribed an SSRI and an anticonvulsant (usually valproate), and were followed up for 12 weeks.