Publications by authors named "Valerio D Bono"
Background: Ceftobiprole is approved in Europe for treatment of community-acquired pneumonia and non-ventilator-associated hospital-acquired pneumonia (HAP) in adults. Real-world data are limited.
Methods: This multi-centre, observational, ambispective investigator-initiated study was undertaken in Italy from January 2018 to December 2019 in order to evaluate the use of ceftobiprole in a real-world setting.
Article Synopsis
- This study investigated the relationship between different types of respiratory support and the risk of barotrauma in COVID-19 patients during hospital stays from March 2020 to February 2021.
- It found that invasive mechanical ventilation and non-invasive ventilation (C-PAP/PSV) significantly increased the risk of barotrauma compared to conventional oxygen therapy, while High Flow Nasal Oxygen (HFNO) did not.
- The occurrence of barotrauma was low (1.00%) but was associated with older age, immunosuppression, and a higher risk of in-hospital death.
In the last decade, carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has become endemic in several countries, including Italy. In the present study, we assessed the differences in epidemiology, management, and mortality of CR-Kp bloodstream infection (BSI) in the three main adult acute-care hospitals of the metropolitan area of Genoa, Italy. From January 2013 to December 2014, all patients with CR-Kp BSI were identified through the computerized microbiology laboratory databases of the three hospitals.
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