Publications by authors named "Valerie Wiener"
Vertigo patients frequently complain of emotional and associated cognitive problems, yet currently, there is no satisfactory questionnaire to measure these associated problems. In the present paper, we propose a new internet-based Neuropsychological Vertigo Inventory (NVI; French) that evaluates attention, memory, emotion, space perception, time perception, vision, and motor abilities. The questionnaire was created using four steps: (1) open interviews with patients suffering from vertigo; (2) semi-structured interviews with an analysis grid to quantify and define the various cognitive and emotional problems reported by the patients; (3) a first version of an internet questionnaire tested on 108 vertigo participants; and (4) the selection of subscale items using principal component analyses (PCA).
View Article and Find Full Text PDFArticle Synopsis
- A patient with downbeat nystagmus underwent multiple positron emission tomography (PET) scans to assess brain metabolism while off and on treatment with 4-aminopyridine.
- The scans revealed lower cerebral glucose metabolism in specific regions of the brain (cerebellar tonsil and (para-) flocculus) when compared to healthy individuals' data.
- Treatment with 4-aminopyridine appeared to improve this hypometabolism, suggesting the cerebellar areas are significant in regulating downbeat nystagmus through inhibition of vestibular circuits.