Publications by authors named "Valerie U Nguyen"
Article Synopsis
- Ewing sarcoma is a cancer primarily affecting children and young adults, driven by the fusion protein EWSR1::FLI1, which disrupts normal chromatin function and gene regulation.
- Researchers developed a high-throughput screening platform to identify small molecules that can modify chromatin accessibility, leading to the discovery of MS0621, which suppresses the growth of Ewing sarcoma cells through cell cycle arrest.
- MS0621 was found to interact with both RNA splicing and chromatin regulatory proteins in an RNA-independent manner, suggesting it alters chromatin activity and offers a promising target for future treatments based on chromatin dysregulation mechanisms.
