Publications by authors named "Valerie Pires"
Article Synopsis
- The study investigates how polystyrene nanoplastics (PS-NPLs) affect the toxicity of haloperidol on tadpoles of two amphibian species, Xenopus laevis and Pelophylax perezi, using both in vivo and in vitro methods.
- Findings indicate that Xenopus laevis tadpoles are more vulnerable to the toxic effects of haloperidol compared to Pelophylax perezi, with specific lethal concentrations recorded.
- While PS-NPLs didn't overall change haloperidol's toxicity, they decreased the occurrence of malformations in tadpoles and increased lethality at low concentrations, suggesting a complex relationship between nanoplastics and pharmaceuticals.
Toothpicks are commonly used household items that rarely cause serious injury or infection. Toothpick-related injuries often occur due to ingestion with subsequent trauma/infection at distal sites within the gastrointestinal tract; however, cardiovascular, pleural, and soft tissue infections have been reported. Eikenella corrodens is a gram-negative, facultative anaerobic bacillus found in oral flora associated with bite wound infections.
View Article and Find Full Text PDFInflammatory cytokine response to injury in the aging rabbit subglottis.
Ann Otol Rhinol Laryngol
February 2009
Objectives: We performed a pilot study to determine whether there is an age-related change in inflammatory expression in the subglottic mucosa of rabbits in response to a one-time injury.
Methods: Twenty-seven rabbits of 3 different ages meant to represent infant, adolescent, and adult stages underwent a unilateral, subglottic soft tissue injury. The animal groups were allowed to heal for 3 different durations to reflect the early, middle, and late stages of inflammation.
Objective: To determine if subglottic development is at least partially under local control and to determine which tissue layer(s) is predominantly responsible.
Design: The suglottises of 12 day-3 CD1 mice were grown in whole organ culture. The 12 subglottises were divided into 3 individual groups: +++, -++, and ---.
Article Synopsis
- The study aimed to identify which structural proteins in tracheal cartilage are lost during inflammation and to see if damaged cartilage can regenerate, especially with age.
- Using immunohistochemical analysis, researchers examined human tracheal samples to detect loss of collagen types and aggrecan.
- Results showed that collagen type I and aggrecan were lost in severely damaged areas, but some regenerative capacity was present, primarily with collagen type II, and this capacity was not influenced by the age of the specimens.